Jeannie Lee headshot

Jeannie T. Lee, M.D., Ph.D.

Phillip A. Sharp Chair in Molecular Biology, Massachusetts General Hospital
Vice Chair of the Department of Genetics, Harvard Medical School
Professor of Genetics and Pathology, Harvard Medical School
617-726-5943
Lee Lab Website
Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression.
Authors: Authors: Rosenberg M, Blum R, Kesner B, Maier VK, Szanto A, Lee JT.
Cell Syst
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Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1).
Authors: Authors: Sunwoo H, Colognori D, Froberg JE, Jeon Y, Lee JT.
Proc Natl Acad Sci U S A
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TERRA RNA Antagonizes ATRX and Protects Telomeres.
Authors: Authors: Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT.
Cell
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Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing".
Authors: Authors: Wang CY, Froberg JE, Blum R, Jeon Y, Lee JT.
Science
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The X chromosome in space.
Authors: Authors: Jégu T, Aeby E, Lee JT.
Nat Rev Genet
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Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-ß superfamily as a regulator of XIST expression.
Authors: Authors: Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A.
Proc Natl Acad Sci U S A
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Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.
Authors: Authors: Kundu S, Ji F, Sunwoo H, Jain G, Lee JT, Sadreyev RI, Dekker J, Kingston RE.
Mol Cell
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Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
Authors: Authors: Savol AJ, Wang PI, Jeon Y, Colognori D, Yildirim E, Pinter SF, Payer B, Lee JT, Sadreyev RI.
PLoS One
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Destabilization of B2 RNA by EZH2 Activates the Stress Response.
Authors: Authors: Zovoilis A, Cifuentes-Rojas C, Chu HP, Hernandez AJ, Lee JT.
Cell
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A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.
Authors: Authors: Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT.
Proc Natl Acad Sci U S A
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