Joel Hirschhorn headshot

Joel Naom Hirschhorn, M.D., Ph.D.

Chief of the Division of Endocrinology, Boston Children's Hospital
Concordia Professor of Pediatrics and Professor of Genetics, Harvard Medical School.
617-919-2129
Hirschhorn Lab Website
Accelerated Epigenetic Ageing in Diabetic Kidney Disease: A Comparison of 10 Epigenetic Clock Measures in Individuals With Type 1 Diabetes.
Authors: Authors: Hill C, Luo X, Syreeni A, Smyth L, Dahlström EH, Duffy S, Kilner J, Mangani A, Jenkins AJ, McKay G, Maxwell AP, Brennan EP, Godson C, Hirschhorn JN, Florez JC, Groop PH, Sandholm N, McKnight AJ.
Diabetes
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Genetic risk for PCOS/PMOS is associated with hyperandrogenism but not irregular menses in adolescents and young adults.
Authors: Authors: Lingadal V, DiMeo M, Hirschhorn JN, Chan YM, Zhu J.
J Endocr Soc
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Genetics of Obesity: Discovery, Biology, Prediction, and Therapeutic Implications.
Authors: Authors: Babinski MA, Loos RJF, Berndt SI, Hirschhorn JN.
Annu Rev Med
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Long-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease.
Authors: Authors: Luo X, Syreeni A, Hill C, Smyth LJ, Dahlström EH, Mutter S, Chen Z, Natarajan R, Pan S, Parton A, Jackson H, McKay G, Susztak K, Hirschhorn JN, Florez JC, Maxwell AP, Groop PH, McKnight AJ, Sandholm N.
medRxiv
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Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".
Authors: Authors: Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK, Ha E, Syreeni A, Dahlström EH, Salem RM, Fermin D, Mercader J, Smyth L, Hill C, Mychaleckyj J, McGurnaghan S, Miller RG, Costacou T, Snell-Bergeon J, Paterson AD, Verkauskiene R, Sokolovska J, Panduru NM, Zerbini G, Brismar K, Krolewski AS, Harjutsalo V, Rossing P, Hadjadj S, McKay G, McKnight AJ, Maxwell AP, Susztak K, Godson C, Kretzler M, Hirschhorn JN, Florez JC, Groop PH.
Kidney Int Rep
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Genetics of skeletal proportions across two different populations.
Authors: Authors: Bartell E, Lin K, Tsuo K, Gan W, Vedantam S, Cole JB, Baronas JM, Yengo L, Marouli E, Amariuta T, Chen Z, Li L, Renthal NE, Jacobsen CM, Salem RM, Walters RG, Hirschhorn JN.
Am J Hum Genet
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Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.
Authors: Authors: Moolhuijsen LME, Zhu J, Mullin BH, Pujol-Gualdo N, Actkins KV, Mack JA, Rao H, Trivedi B, Kentistou KA, Zhao Y, Westergaard D, Tyrmi JS, Thorleifsson G, Zhang Y, Wittemans L, DeVries A, Brewer K, Sisk R, Danning R, Preuss MH, Jones MR, Ruth KS, Andersen M, Azziz R, Banasik K, Boehnke M, Broer L, Brunak S, Chan YM, Chasman DI, Daly M, Ehrmann DA, Fauser BC, Fritsche LG, Hayes MG, He C, Huang H, Kowalska I, Kraft P, Legro RS, Lin N, Loos RJ, Louwers YV, Magi R, McCarthy MI, Morin-Papunen L, Morrison JV, Morton C, Nadkarni GN, Neale BM, Nielsen HS, Nyegaard M, Ostrowski SR, Pedersen OBV, Sørensen E, Mikkelsen C, Erikstrup C, Kaspersen KA, Bruun MT, Aagaard B, Ullum H, Obermayer-Pietsch B, Palotie A, Reeve MP, Salumets A, Saxena R, Spector TD, Stuckey BGA, Thorsteinsdottir U, Uitterlinden AG, Urbanek M, Zöllner S, van Heel DA, Hirschhorn JN, Stefansson K, Perry JRB, Styrkarsdottir U, Wilson SG, Piltonen T, Laisk T, Jarvelin MR, Burns K, Justice AE, Laivuori H, Ong KK, Goodarzi MO, Davis LK, Dunaif A, Lindgren CM, Laven JSE, Franks S, Visser JA, Welt CK, Karaderi T, Day FR.
Nat Genet
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Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes.
Authors: Authors: Syreeni A, Dahlström EH, Smyth LJ, Hill C, Mutter S, Harjutsalo V, Chen Z, Natarajan R, Krolewski AS, Hirschhorn JN, Florez JC, Maxwell AP, Groop PH, McKnight AJ, Sandholm N.
Diabetologia
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Genetics of skeletal proportions across two different populations.
Authors: Authors: Bartell E, Lin K, Tsuo K, Gan W, Vedantam S, Cole JB, Baronas JM, Yengo L, Marouli E, Amariuta T, Chen Z, Li L, Renthal NE, Jacobsen CM, Salem RM, Walters RG, Hirschhorn JN.
Am J Hum Genet
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Weight-independent effects of dietary carbohydrate-to-fat ratio on metabolomic profiles: secondary outcomes of a 5-month randomized controlled feeding trial.
Authors: Authors: Angelidi AM, Bartell E, Huang Y, Zeleznik OA, Estanyol-Torres N, Mi MY, Bhupathiraju SN, Kelly RS, Wittenbecher C, Lasky-Su J, Clish CB, Ludwig DS, Ebbeling CB, Hirschhorn JN.
Nat Commun
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