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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy.
Authors: Authors: Yadin D, Guetta T, Petrover Z, Alcalai R, Seidman J, Seidman CE, Ofek E, Kornowski R, Hochhauser E, Arad M.
Biochem Pharmacol
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Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1.
Authors: Authors: Shi W, Scialdone AP, Emerson JI, Mei L, Wasson LK, Davies HA, Seidman CE, Seidman JG, Cook JG, Conlon FL.
Circ Res
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Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes.
Authors: Authors: Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, Amgalan D, Rosa Ma X, Pereira A, Tcheandjieu C, Seidman C, Seidman J, Tristani-Firouzi M, Chung W, Goldmuntz E, Srivastava D, Loos RJF, Chami N, Cordell H, Dreßen M, Mueller-Myhsok B, Lahm H, Krane M, Pollard KS, Engreitz JM, Gagliano Taliun SA, Gelb BD, Priest JR.
Circ Genom Precis Med
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Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease.
Authors: Authors: Jang MY, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb BD, Porter GA, Seidman CE, Seidman JG.
Circ Genom Precis Med
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Tbx5 maintains atrial identity by regulating an atrial enhancer network.
Authors: Authors: Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT.
bioRxiv
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Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling.
Authors: Authors: Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A.
Int J Mol Sci
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Structural variation across 138,134 samples in the TOPMed consortium.
Authors: Authors: Jun G, English A, Metcalf G, Yang J, Chaisson M, Pankratz N, Menon V, Salerno W, Krasheninina O, Smith A, Lane J, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett D, Ashley-Koch A, Auer P, Beutel K, Bis J, Blangero J, Bowden D, Brody J, Cade B, Chen YI, Cho M, Curran J, Fornage M, Frredman B, Fingerlin T, Gelb B, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos R, Marcus G, Mathias R, McGarvey S, Montgomery C, Naseri T, Nouraie S, Preuss M, Palmer N, Peyser P, Raffield L, Ratan A, Redline S, Reupena M, Rotter J, Rich S, Rienstra M, Ruczinski I, Sankaran V, Schwartz D, Seidman C, Seidman J, Silverman E, Smith J, Stilp A, Taylor K, Telen M, Weiss S, Williams LK, Wu B, Yanek L, Zhang Y, Lasky-Su J, Gingras MC, Dutcher S, Eichler E, Gabriel S, Germer S, Kim R, Martinez K, Nickerson D, Luo J, Reiner A, Gibbs R, Boerwinkle E, Abecasis G, Sedlazeck F.
Res Sq
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Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice.
Authors: Authors: Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C.
Nat Med
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mTOR signaling inhibition decreases lysosome migration and impairs the success of Trypanosoma cruzi infection and replication in cardiomyocytes.
Authors: Authors: Alvim JM, Venturini G, Oliveira TGM, Seidman JG, Seidman CE, Krieger JE, Pereira AC.
Acta Trop
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Structural variation across 138,134 samples in the TOPMed consortium.
Authors: Authors: Jun G, English AC, Metcalf GA, Yang J, Chaisson MJ, Pankratz N, Menon VK, Salerno WJ, Krasheninina O, Smith AV, Lane JA, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett DK, Ashley-Koch A, Auer PL, Beutel KM, Bis JC, Blangero J, Bowden DW, Brody JA, Cade BE, Chen YI, Cho MH, Curran JE, Fornage M, Freedman BI, Fingerlin T, Gelb BD, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos RJF, Marcus GM, Mathias RA, McGarvey ST, Montgomery C, Naseri T, Nouraie SM, Preuss MH, Palmer ND, Peyser PA, Raffield LM, Ratan A, Redline S, Reupena S, Rotter JI, Rich SS, Rienstra M, Ruczinski I, Sankaran VG, Schwartz DA, Seidman CE, Seidman JG, Silverman EK, Smith JA, Stilp A, Taylor KD, Telen MJ, Weiss ST, Williams LK, Wu B, Yanek LR, Zhang Y, Lasky-Su J, Gingras MC, Dutcher SK, Eichler EE, Gabriel S, Germer S, Kim R, Viaud-Martinez KA, Nickerson DA, Luo J, Reiner A, Gibbs RA, Boerwinkle E, Abecasis G, Sedlazeck FJ.
bioRxiv
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