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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
Authors: Authors: Song L, Alcalai R, Arad M, Wolf CM, Toka O, Conner DA, Berul CI, Eldar M, Seidman CE, Seidman JG.
J Clin Invest
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A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Authors: Authors: Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE.
Cell
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Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy.
Authors: Authors: Kim JB, Porreca GJ, Song L, Greenway SC, Gorham JM, Church GM, Seidman CE, Seidman JG.
Science
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Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.
Authors: Authors: Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R.
J Clin Invest
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AMP-activated protein kinase in the heart: role during health and disease.
Authors: Authors: Arad M, Seidman CE, Seidman JG.
Circ Res
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Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome.
Authors: Authors: Hinson JT, Fantin VR, Schönberger J, Breivik N, Siem G, McDonough B, Sharma P, Keogh I, Godinho R, Santos F, Esparza A, Nicolau Y, Selvaag E, Cohen BH, Hoppel CL, Tranebjaerg L, Eavey RD, Seidman JG, Seidman CE.
N Engl J Med
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Complex genomic rearrangement in CCS-LacZ transgenic mice.
Authors: Authors: Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI.
Genesis
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Cardiac myosin binding protein C phosphorylation is cardioprotective.
Authors: Authors: Sadayappan S, Osinska H, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Seidman CE, Seidman JG, Robbins J.
Proc Natl Acad Sci U S A
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Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
Authors: Authors: Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG.
Proc Natl Acad Sci U S A
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Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Authors: Authors: Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG.
Dev Biol
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