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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.
Authors: Authors: Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE.
Science
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Phenotypic diversity in hypertrophic cardiomyopathy.
Authors: Authors: Arad M, Seidman JG, Seidman CE.
Hum Mol Genet
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Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy.
Authors: Authors: Ho CY, Sweitzer NK, McDonough B, Maron BJ, Casey SA, Seidman JG, Seidman CE, Solomon SD.
Circulation
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The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.
Authors: Authors: Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG.
J Clin Invest
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Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome.
Authors: Authors: Coll M, Seidman JG, Müller CW.
Structure
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Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.
Authors: Authors: Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF.
Circulation
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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Authors: Authors: Gerull B, Gramlich M, Atherton J, McNabb M, Trombitás K, Sasse-Klaassen S, Seidman JG, Seidman C, Granzier H, Labeit S, Frenneaux M, Thierfelder L.
Nat Genet
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Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
Authors: Authors: Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kanter RJ, McGarry K, Seidman JG, Seidman CE.
J Clin Invest
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Transcription factor haploinsufficiency: when half a loaf is not enough.
Authors: Authors: Seidman JG, Seidman C.
J Clin Invest
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Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Authors: Authors: Niimura H, Patton KK, McKenna WJ, Soults J, Maron BJ, Seidman JG, Seidman CE.
Circulation
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