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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.
Authors: Authors: Hardt SE, Geng YJ, Montagne O, Asai K, Hong C, Yang GP, Bishop SP, Kim SJ, Vatner DE, Seidman CE, Seidman JG, Homcy CJ, Vatner SF.
Circulation
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Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
Authors: Authors: Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kanter RJ, McGarry K, Seidman JG, Seidman CE.
J Clin Invest
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Transcription factor haploinsufficiency: when half a loaf is not enough.
Authors: Authors: Seidman JG, Seidman C.
J Clin Invest
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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.
Authors: Authors: Gerull B, Gramlich M, Atherton J, McNabb M, Trombitás K, Sasse-Klaassen S, Seidman JG, Seidman C, Granzier H, Labeit S, Frenneaux M, Thierfelder L.
Nat Genet
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Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Authors: Authors: Niimura H, Patton KK, McKenna WJ, Soults J, Maron BJ, Seidman JG, Seidman CE.
Circulation
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Molecular epidemiology of hypertrophic cardiomyopathy.
Authors: Authors: Morita H, DePalma SR, Arad M, McDonough B, Barr S, Duffy C, Maron BJ, Seidman CE, Seidman JG.
Cold Spring Harb Symp Quant Biol
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Causes of clinical diversity in human TBX5 mutations.
Authors: Authors: Huang T, Lock JE, Marshall AC, Basson C, Seidman JG, Seidman CE.
Cold Spring Harb Symp Quant Biol
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The coming of age of cardiovascular science.
Authors: Authors: Seidman CE, Seidman JG.
Cold Spring Harb Symp Quant Biol
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A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
Authors: Authors: Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S.
Cold Spring Harb Symp Quant Biol
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Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Authors: Authors: Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG.
Circulation
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