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Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics, Harvard Medical School
617-432-7830
Seidman Lab Website
Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity.
Authors: Authors: Morton SU, Pereira AC, Quiat D, Richter F, Kitaygorodsky A, Hagen J, Bernstein D, Brueckner M, Goldmuntz E, Kim RW, Lifton RP, Porter GA, Tristani-Firouzi M, Chung WK, Roberts A, Gelb BD, Shen Y, Newburger JW, Seidman JG, Seidman CE.
Circ Genom Precis Med
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Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome.
Authors: Authors: Meier AB, Raj Murthi S, Rawat H, Toepfer CN, Santamaria G, Schmid M, Mastantuono E, Schwarzmayr T, Berutti R, Cleuziou J, Ewert P, Görlach A, Klingel K, Laugwitz KL, Seidman CE, Seidman JG, Moretti A, Wolf CM.
iScience
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cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy
Authors: Authors: Different Transcriptomic Response to T
Front Cell Infect Microbiol
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Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart.
Authors: Authors: Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD, Pilbrow AP.
Int J Mol Sci
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Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.
Authors: Authors: Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS.
Sci Adv
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LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart.
Authors: Authors: Alcalai R, Arad M, Wakimoto H, Yadin D, Gorham J, Wang L, Burns E, Maron BJ, Roberts WC, Konno T, Conner DA, Perez-Atayde AR, Seidman JG, Seidman CE.
J Am Heart Assoc
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Contribution of Noncanonical Splice Variants to TTN Truncating Variants Cardiomyopathy.
Authors: Authors: Patel PN, Ito K, Willcox JAL, Haghighi A, Jang MY, Gorham JM, DePalma SR, Lam L, McDonough B, Johnson R, Lakdawala NK, Roberts A, Barton PJR, Cook SA, Fatkin D, Seidman CE, Seidman JG.
Circ Genom Precis Med
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Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation.
Authors: Authors: Agarwal R, Paulo J, Toepfer CN, Ewoldt JK, Sundaram S, Chopra A, Zhang Q, Gorham J, DePalma S, Chen CS, Gygi S, Seidman CE, Seidman JG.
Circ Res
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Genomic frontiers in congenital heart disease.
Authors: Authors: Morton SU, Quiat D, Seidman JG, Seidman CE.
Nat Rev Cardiol
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CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes.
Authors: Authors: Psaras Y, Margara F, Cicconet M, Sparrow AJ, Repetti GG, Schmid M, Steeples V, Wilcox JAL, Bueno-Orovio A, Redwood CS, Watkins HC, Robinson P, Rodriguez B, Seidman JG, Seidman CE, Toepfer CN.
Circ Res
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