Our mission is to uncover the missing link between repeat DNA, genome stability, and viral infection that underlies the etiology of virus-associated cancer and genetic diseases.
Our lab is officially opening in September 2024! We are seeking to recruit fellows, students, and technicians who share our passion in repeat DNA, genomic instability, and viruses. We are a part of the Program in Cellular and Molecular Medicine at Boston Children's Hospital and the Department of Genetics at Harvard Medical School, situated at the heart of the vibrant scientific community of the Longwood Medical Area in Boston. If you are interested in joining our team, please send an email to julia.li@childrens.harvard.edu
Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats.
Authors: Li JSZ, Abbasi A, Kim DH, Lippman SM, Alexandrov LB, Cleveland DW.
Nature 2023-04-12
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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells.
Authors: Moreno SP, Miralles Fueste J, Kaiser M, Li JSZ, Nassour J, Haggblom C, Lazzerini Denchi E, Karlseder J.
iScience 2023-03-14
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Chromothripsis drives the evolution of gene amplification in cancer.
Authors: Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW.
Nature 2021-03
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Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres.
Authors: Loe TK, Li JSZ, Zhang Y, Azeroglu B, Boddy MN, Denchi EL.
Genes Dev 2020-05-01
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How stem cells keep telomeres in check.
Authors: Li JSZ, Denchi EL.
Differentiation 2018-02-02
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TZAP: A telomere-associated protein involved in telomere length control.
Authors: Li JSZ, Miralles Fuste J, Simavorian T, Bartocci C, Tsai J, Karlseder J, Lazzerini Denchi E.
Science 2017-02-10
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Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost.
Authors: Benoit RM, Ostermeier C, Geiser M, Li JSZ, Widmer H, Auer, M.
PLoS One 2016-04-13
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Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients.
Authors: Ruiz C, Li J, Luttgen MS, Kolatkar A, Kendall JT, Flores E, Topp Z, Samlowski WE, McClay E, Bethel K, Ferrone S, Hicks J, Kuhn, P.
Phys Biol 2015-01-09
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Let it go: how to deal with a breakup in mitosis.
Authors: Denchi EL, Li JSZ.
Nat Struct Mol Biol 2014-05
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Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions.
Authors: Bartocci C, Diedrich JK, Ouzounov I, Li JSZ, Piunti A, Pasini D, Yates JR 3rd, Lazzerini Denchi E.
Cell Reports 2014-05-22
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