Konrad Hochedlinger

Konrad Hochedlinger, Ph.D.

Professor of Genetics, Massachusetts General Hospital
617-643-2075
Konrad Hochedlinger Website
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.
Authors: Authors: Huebner AJ, Gorelov RA, Deviatiiarov R, Demharter S, Kull T, Walsh RM, Taylor MS, Steiger S, Mullen JT, Kharchenko PV, Hochedlinger K.
Nat Cell Biol
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Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.
Authors: Authors: Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B.
Proc Natl Acad Sci U S A
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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.
Authors: Authors: Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S.
Nat Commun
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Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.
Authors: Authors: Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA.
Genes Dev
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Chromatin-state barriers enforce an irreversible mammalian cell fate decision.
Authors: Authors: Blanco MA, Sykes DB, Gu L, Wu M, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Cheloufi S, Meissner A, Hochedlinger K, Scadden DT, Shi Y.
Cell Rep
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Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
Authors: Authors: Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ.
Genes Dev
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Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells.
Authors: Authors: Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, Di Stefano B, Tsopoulidis N, Hoetker MS, Huebner AJ, Bar-Nur O, Almada AE, Yamamoto M, Patelunas A, Goldhamer DJ, Wagers AJ, Michor F, Meissner A, Sadreyev RI, Hochedlinger K.
Genes Dev
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Reprogramming to recover youthful epigenetic information and restore vision.
Authors: Authors: Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA.
Nature
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Renewed proliferation in adult mouse cochlea and regeneration of hair cells.
Authors: Authors: Shu Y, Li W, Huang M, Quan YZ, Scheffer D, Tian C, Tao Y, Liu X, Hochedlinger K, Indzhykulian AA, Wang Z, Li H, Chen ZY.
Nat Commun
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Reprogramming: identifying the mechanisms that safeguard cell identity.
Authors: Authors: Brumbaugh J, Di Stefano B, Hochedlinger K.
Development
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