Konrad Hochedlinger, Ph.D.
Professor of Genetics, Massachusetts General Hospital
A cellular identity crisis? Plasticity changes during aging and rejuvenation.
Manipulating cell fate through reprogramming: approaches and applications.
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks.
Authors: Authors: Gorelov R, Weiner A, Huebner A, Yagi M, Haghani A, Brooke R, Horvath S, Hochedlinger K.
Stem Cell Reports
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Stem Cell Reports
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Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome.
Authors: Authors: LeBleu VS, Kanasaki K, Lovisa S, Alge JL, Kim J, Chen Y, Teng Y, Gerami-Naini B, Sugimoto H, Kato N, Revuelta I, Grau N, Sleeman JP, Taduri G, Kizu A, Rafii S, Hochedlinger K, Quaggin SE, Kalluri R.
Life Sci Alliance
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Life Sci Alliance
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H3K36 methylation maintains cell identity by regulating opposing lineage programmes.
Authors: Authors: Hoetker MS, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong LP, Huebner AJ, Charlton J, Deng W, Haggerty C, Sadreyev RI, Meissner A, Michor F, Plath K, Hochedlinger K.
Nat Cell Biol
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Nat Cell Biol
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Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis.
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.
Authors: Authors: Huebner AJ, Gorelov RA, Deviatiiarov R, Demharter S, Kull T, Walsh RM, Taylor MS, Steiger S, Mullen JT, Kharchenko PV, Hochedlinger K.
Nat Cell Biol
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Nat Cell Biol
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Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.
Authors: Authors: Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.
Authors: Authors: Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S.
Nat Commun
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Nat Commun
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Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.
Authors: Authors: Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA.
Genes Dev
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Genes Dev
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