Louis Kunkel headshot

Louis Martens Kunkel, Ph.D.

Professor of Genetics and Pediatrics, Harvard Medical School
Director, Genomics Program
617-355-7576
Kunkel Lab Website
A high-resolution map of human chromosome 12.
Authors: Authors: Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R.
Nature
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Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
Authors: Authors: Yang WC, Mathew J, Velcich A, Edelmann W, Kucherlapati R, Lipkin M, Yang K, Augenlicht LH.
Cancer Res
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Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency.
Authors: Authors: Kuraguchi M, Edelmann W, Yang K, Lipkin M, Kucherlapati R, Brown AM.
Oncogene
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Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.
Authors: Authors: Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R.
Genes Chromosomes Cancer
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Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6.
Authors: Authors: Ion A, Crosby AH, Kremer H, Kenmochi N, Van Reen M, Fenske C, Van Der Burgt I, Brunner HG, Montgomery K, Kucherlapati RS, Patton MA, Page C, Mariman E, Jeffery S.
J Med Genet
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High-resolution transcript map of the region spanning D12S1629 and D12S312 at chromosome 12q13: triple A syndrome-linked region.
Authors: Authors: Lee H, Choi E, Seomun Y, Montgomery K, Huebner A, Lee E, Lau S, Joo CK, Kucherlapati R, Yoon SJ.
Genome Res
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Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption.
Authors: Authors: Marcus DM, Rustgi AK, Defoe D, Kucherlapati R, Edelmann W, Hamasaki D, Liou GI, Smith SB.
Mol Vis
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Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
Authors: Authors: Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT.
J Clin Invest
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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.
Authors: Authors: Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E.
Nat Med
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Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Authors: Authors: Puech A, Saint-Jore B, Merscher S, Russell RG, Cherif D, Sirotkin H, Xu H, Factor S, Kucherlapati R, Skoultchi AI.
Proc Natl Acad Sci U S A
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