Luke H Chao

Luke H Chao, Ph.D.

Assistant Professor of Genetics, Harvard Medical School

617-724-2323

Chao Lab Website

Publications

Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates.

Authors: Authors: Chao LH, Avruch J.
F1000Res 2019-01-01
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How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion.

Authors: Authors: Chao LH, Jang J, Johnson A, Nguyen A, Gray NS, Yang PL, Harrison SC.
Elife 2018-07-12
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Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.

Authors: Authors: Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R.
J Virol 2016-05-01
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Sequential conformational rearrangements in flavivirus membrane fusion.

Authors: Authors: Chao LH, Klein DE, Schmidt AG, Peña JM, Harrison SC.
Elife 2014-12-05
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Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.

Authors: Authors: Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J.
Elife 2014-01-28
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Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Authors: Authors: Stratton MM, Chao LH, Schulman H, Kuriyan J.
Curr Opin Struct Biol 2013-04-01
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A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.

Authors: Authors: Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J.
Cell 2011-09-02
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Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.

Authors: Authors: Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J.
Nat Struct Mol Biol 2010-03-01
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Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

Authors: Authors: Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J.
Cancer Res 2006-01-15
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Crystal structure of tobacco etch virus protease shows the protein C terminus bound within the active site.

Authors: Authors: Nunn CM, Jeeves M, Cliff MJ, Urquhart GT, George RR, Chao LH, Tscuchia Y, Djordjevic S.
J Mol Biol 2005-07-01
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