Marjorie Ann Oettinger, Ph.D.
Professor of Genetics, Harvard Medical School
Pillars article: the V(D)J recombination activating gene, RAG-1. 1989.
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
Authors: Authors: Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA.
Nature
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Nature
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The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.
Authors: Authors: Ramón-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, Yang W.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
Authors: Authors: Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP.
J Biol Chem
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J Biol Chem
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Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination.
Authors: Authors: Dai Y, Wong B, Yen YM, Oettinger MA, Kwon J, Johnson RC.
Mol Cell Biol
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Mol Cell Biol
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The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast.
Authors: Authors: Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA.
J Biol Chem
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J Biol Chem
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Molecular biology: hairpins at split ends in DNA.
ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays.
How to keep V(D)J recombination under control.
Ordered DNA release and target capture in RAG transposition.