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Matthew L. Warman, M.D.

Professor of Genetics
617-919-2371
Matt Warman Website
Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature.
Authors: Authors: Olney RC, Bükülmez H, Bartels CF, Prickett TC, Espiner EA, Potter LR, Warman ML.
J Clin Endocrinol Metab
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Somatic mosaicism in a male with an exon skipping mutation in PDHA1 of the pyruvate dehydrogenase complex results in a milder phenotype.
Authors: Authors: Okajima K, Warman ML, Byrne LC, Kerr DS.
Mol Genet Metab
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Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families.
Authors: Authors: Bukulmez H, Matthews AL, Sullivan CM, Chen C, Kraay MJ, Elston RC, Moskowitz RW, Goldberg VM, Warman ML.
Arthritis Res Ther
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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice.
Authors: Authors: Clément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G.
Proc Natl Acad Sci U S A
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Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.
Authors: Authors: Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, Laxer R, Goldbach-Mansky R, Warman ML.
J Biol Chem
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The role of sequence variations within the genes encoding collagen II, IX and XI in non-syndromic, early-onset osteoarthritis.
Authors: Authors: Jakkula E, Melkoniemi M, Kiviranta I, Lohiniva J, Räinä SS, Perälä M, Warman ML, Ahonen K, Kröger H, Göring HH, Ala-Kokko L.
Osteoarthritis Cartilage
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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling.
Authors: Authors: Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML.
Mol Cell Biol
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Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis.
Authors: Authors: Elsaid KA, Jay GD, Warman ML, Rhee DK, Chichester CO.
Arthritis Rheum
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The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.
Authors: Authors: Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML, Carpten JD.
J Clin Invest
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WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.
Authors: Authors: Kutz WE, Gong Y, Warman ML.
Mol Cell Biol
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