Norbert Perrimon headshot

Norbert Perrimon, Ph.D.

James Stillman Professor of Developmental Biology, Harvard Medical School
Investigator, Howard Hughes Medical Institute
617-432-7672
Perrimon Lab Website
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
Authors: Authors: Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N.
Sci Signal
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BIOSAFETY. Safeguarding gene drive experiments in the laboratory.
Authors: Authors: Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J.
Science
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Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells.
Authors: Authors: Mohr SE, Hu Y, Rudd K, Buckner M, Gilly Q, Foster B, Sierzputowska K, Comjean A, Ye B, Perrimon N.
G3 (Bethesda)
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Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Authors: Authors: Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC.
Dev Cell
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A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs.
Authors: Authors: Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D.
Nat Commun
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Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
Authors: Authors: Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N.
Dev Cell
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Highly efficient Cas9-mediated transcriptional programming.
Authors: Authors: Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.
Nat Methods
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A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.
Authors: Authors: Sopko R, Lin YB, Makhijani K, Alexander B, Perrimon N, Brückner K.
PLoS Genet
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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Authors: Authors: Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD.
Proc Natl Acad Sci U S A
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Regulators of autophagosome formation in Drosophila muscles.
Authors: Authors: Zirin J, Nieuwenhuis J, Samsonova A, Tao R, Perrimon N.
PLoS Genet
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