Norbert Perrimon, Ph.D.
James Stillman Professor of Developmental Biology, Harvard Medical School
Investigator, Howard Hughes Medical Institute
Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.
Expression of I-Sce I in Drosophila to induce DNA double-strand breaks.
Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.
Authors: Authors: Cleghon V, Feldmann P, Ghiglione C, Copeland TD, Perrimon N, Hughes DA, Morrison DK.
Mol Cell
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Mol Cell
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Dual function of Ras in Raf activation.
Developmental biology. Sending all the right signals.
Frizzled signaling and the developmental control of cell polarity.
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.
Authors: Authors: Harrison DA, McCoon PE, Binari R, Gilman M, Perrimon N.
Genes Dev
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Genes Dev
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New advances in Drosophila provide opportunities to study gene functions.
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
Authors: Authors: Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N.
Genes Dev
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Genes Dev
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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.