Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse.
Authors: Authors: Willemsen R, Tybulewicz V, Sidransky E, Eliason WK, Martin BM, LaMarca ME, Reuser AJ, Tremblay M, Westphal H, Mulligan RC, et al.
Mol Chem Neuropathol
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Gene transfer as cancer therapy.
Authors: Authors: Dranoff G, Mulligan RC.
Adv Immunol
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Pathway-specific regulation of the synthesis of anticoagulantly active heparan sulfate.
Authors: Authors: Shworak NW, Shirakawa M, Colliec-Jouault S, Liu J, Mulligan RC, Birinyi LK, Rosenberg RD.
J Biol Chem
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Transgenic animals as tools for the study of fibrinolysis in vivo.
Authors: Authors: Carmeliet P, Mulligan RC, Collen D.
J Intern Med
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Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis.
Authors: Authors: Vogt PM, Thompson S, Andree C, Liu P, Breuing K, Hatzis D, Brown H, Mulligan RC, Eriksson E.
Proc Natl Acad Sci U S A
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Characterization of ryudocan glycosaminoglycan acceptor sites.
Authors: Authors: Shworak NW, Shirakawa M, Mulligan RC, Rosenberg RD.
J Biol Chem
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Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells.
Authors: Authors: Conte MS, Birinyi LK, Miyata T, Fallon JT, Gold HK, Whittemore AD, Mulligan RC.
Circulation
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Physiological consequences of loss of plasminogen activator gene function in mice.
Authors: Authors: Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC.
Nature
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Demonstration of a rational strategy for human prostate cancer gene therapy.
Authors: Authors: Sanda MG, Ayyagari SR, Jaffee EM, Epstein JI, Clift SL, Cohen LK, Dranoff G, Pardoll DM, Mulligan RC, Simons JW.
J Urol
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Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.
Authors: Authors: Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC.
Genes Dev
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