Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell.
Authors: Authors: Butler MO, Lee JS, Ansén S, Neuberg D, Hodi FS, Murray AP, Drury L, Berezovskaya A, Mulligan RC, Nadler LM, Hirano N.
Clin Cancer Res
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PPARalpha deficiency in inflammatory cells suppresses tumor growth.
Authors: Authors: Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D.
PLoS One
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Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli.
Authors: Authors: Hägerkvist R, Mokhtari D, Lindholm C, Farnebo F, Mostoslavsky G, Mulligan RC, Welsh N, Welsh M.
Exp Cell Res
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Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer.
Authors: Authors: Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC.
Proc Natl Acad Sci U S A
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Exogenous control of mammalian gene expression via modulation of translational termination.
Authors: Authors: Murphy GJ, Mostoslavsky G, Kotton DN, Mulligan RC.
Nat Med
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Chimeric T-cell Receptor Therapy for Glioblastoma Multiforme 895.
Authors: Authors: Bullain SS, Szentirmai O, Lin N, Sanchez CE, Mulligan RC, Carter B.
Neurosurgery
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VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
Authors: Authors: Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ.
Nat Med
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Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer.
Authors: Authors: Simons JW, Carducci MA, Mikhak B, Lim M, Biedrzycki B, Borellini F, Clift SM, Hege KM, Ando DG, Piantadosi S, Mulligan R, Nelson WG.
Clin Cancer Res
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XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Authors: Authors: Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW.
Proc Natl Acad Sci U S A
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Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Authors: Authors: Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC.
RNA
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