Richard Mulligan headshot

Richard Charles Mulligan, Ph.D

Mallinckrodt Professor of Genetics and Professor of Pediatrics, Emeritus

Richard C. Mulligan is the Mallinckrodt Professor of Genetics at Harvard Medical School, and Director of the Harvard Gene Therapy Initiative, an integrated effort amongst basic science and clinical investigators at Harvard University and its Affiliated Hospitals directed towards the pre-clinical and clinical evaluation of novel gene-based therapies for inherited and acquired diseases. Professor Mulligan received his B.S. degree from Massachusetts Institute of Technology, and his Ph.D. from the Department of Biochemistry at Stanford University School of Medicine, where he studied under Professor Paul Berg. After receiving postdoctoral training at the Center for Cancer Research at MIT with Professors David Baltimore and Phillip Sharp, Professor Mulligan joined the MIT faculty and subsequently was appointed Professor of Molecular Biology and Member of the Whitehead Institute for Biomedical Research before moving to Children's Hospital and Harvard in 1996. His honors include the MacArthur Foundation Prize, the Rhodes Memorial Award of the American Association for Cancer Research, the ASMB-Amgen Award, and the Nagai Foundation International Prize.

Professor Mulligan is an internationally recognized pioneer in the development of new technologies for transferring genes into mammalian cells. Scientists use the specialized tools created in his laboratory to unravel basic questions about human development and to devise new therapies for the treatment of both inherited diseases and acquired diseases.

Accuracy of diagnoses of HIV-related oral lesions by medical clinicians. Findings from the Women's Interagency HIV Study.
Authors: Authors: Hilton JF, Alves M, Anastos K, Canchola AJ, Cohen M, Delapenha R, Greenspan D, Levine A, MacPhail LA, Micci SJ, Mulligan R, Navazesh M, Phelan J, Tsaknis P.
Community Dent Oral Epidemiol
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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Authors: Authors: Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW.
Nat Cell Biol
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Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering.
Authors: Authors: Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA.
J Biol Chem
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The Psychogeriatric Assessment Scales (PAS): psychometric properties in French and German speaking populations.
Authors: Authors: Mackinnon A, Mulligan R.
Int J Geriatr Psychiatry
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Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer.
Authors: Authors: Kuo CJ, Farnebo F, Yu EY, Christofferson R, Swearingen RA, Carter R, von Recum HA, Yuan J, Kamihara J, Flynn E, D'Amato R, Folkman J, Mulligan RC.
Proc Natl Acad Sci U S A
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Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain.
Authors: Authors: Kuo CJ, LaMontagne KR, Garcia-Cardeña G, Ackley BD, Kalman D, Park S, Christofferson R, Kamihara J, Ding YH, Lo KM, Gillies S, Folkman J, Mulligan RC, Javaherian K.
J Cell Biol
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Direct delivery of leptin to the hypothalamus using recombinant adeno-associated virus vectors results in increased therapeutic efficacy.
Authors: Authors: Lundberg C, Jungles SJ, Mulligan RC.
Nat Biotechnol
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Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein.
Authors: Authors: Snitkovsky S, Niederman TM, Mulligan RC, Young JA.
J Virol
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Plasmid DNA encapsulation and release from solvent diffusion nanospheres.
Authors: Authors: Hirosue S, Müller BG, Mulligan RC, Langer R.
J Control Release
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A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor.
Authors: Authors: Snitkovsky S, Niederman TM, Carter BS, Mulligan RC, Young JA.
J Virol
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