Stephen Elledge headshot

Stephen J. Elledge, Ph.D

Gregor Mendel Professor of Genetics and of Medicine
617-525-4510
Elledge Lab Website
Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.
Authors: Authors: Patten JJ, Keiser PT, Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, do Valle I, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Hulsey-Stubbs S, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RA.
bioRxiv
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V-CARMA: A tool for the detection and modification of antigen-specific T cells.
Authors: Authors: Guo XJ, Elledge SJ.
Proc Natl Acad Sci U S A
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Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.
Authors: Authors: Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A.
Science
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A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.
Authors: Authors: Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ.
Nat Commun
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Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Authors: Authors: Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X.
Nat Commun
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Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids.
Authors: Authors: Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK.
J Immunother Cancer
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Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
Authors: Authors: Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ.
Genes Dev
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High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy.
Authors: Authors: Chen G, Shrock EL, Li MZ, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Phipatanakul W, Schneider L, Oettgen HC, Elledge SJ.
Cell Rep Med
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The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
Authors: Authors: Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ.
Mol Cell
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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Authors: Authors: Martin TD, Patel RS, Cook DR, Choi MY, Patil A, Liang AC, Li MZ, Haigis KM, Elledge SJ.
Science
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