Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Degrons: defining the rules of protein degradation.
Authors: Authors: Zhang Z, Mena EL, Timms RT, Koren I, Elledge SJ.
Nat Rev Mol Cell Biol
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi NC, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
Mol Cell
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Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Authors: Authors: Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.
Genes Dev
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Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development.
Authors: Authors: Nandy A, Petralia F, Porter C, Elledge S, Colombel JF, Snapper SB.
Gastroenterology
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
bioRxiv
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions.
Authors: Authors: Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V.
Neuron
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An RNA Splicing System that Excises Transposons from Animal mRNAs.
Authors: Authors: Zhao LW, Nardone C, Paulo JA, Elledge SJ, Kennedy S.
bioRxiv
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Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Authors: Authors: Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C.
Nat Commun
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The T cell receptor sequence influences the likelihood of T cell memory formation.
Authors: Authors: Lagattuta KA, Kohlgruber AC, Abdelfattah NS, Nathan A, Rumker L, Birnbaum ME, Elledge SJ, Raychaudhuri S.
Cell Rep
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T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics.
Authors: Authors: Abdelfattah NS, Kula T, Elledge SJ.
Immunity
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