Stephen J. Elledge

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital

Professor of Medicine, Brigham and Women's Hospital

617-525-4510

Additional Websites
Publications

Author Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Authors: Authors: Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ.
Nat Cell Biol 2023-12-19
View full abstract on Pubmed

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

Authors: Authors: Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ.
Mol Cell 2023-11-16
View full abstract on Pubmed

TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes.

Authors: Authors: Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Darise Farris A, Muthuswamy SK, Warner BM, Elledge SJ.
Cell 2023-11-16
View full abstract on Pubmed

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

Authors: Authors: Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ.
Mol Cell 2023-09-21
View full abstract on Pubmed

Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Authors: Authors: Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ.
Nat Cell Biol 2023-09-21
View full abstract on Pubmed

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.

Authors: Authors: Gu X, Nardone C, Kamitaki N, Mao A, Elledge SJ, Greenberg ME.
Science 2023-08-25
View full abstract on Pubmed

Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.

Authors: Authors: Liebhoff AM, Venkataraman T, Morgenlander WR, Na M, Kula T, Waugh K, Morrison C, Rewers M, Longman R, Round J, Elledge S, Ruczinski I, Langmead B, Larman HB.
bioRxiv 2023-07-31
View full abstract on Pubmed

Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.

Authors: Authors: Mitchell MM, Leng Y, Boppana S, Britt WJ, Gutierrez Sanchez LH, Elledge SJ.
Sci Transl Med 2023-07-26
View full abstract on Pubmed

ERa-associated translocations underlie oncogene amplifications in breast cancer.

Authors: Authors: Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ.
Nature 2023-06-01
View full abstract on Pubmed

Ubiquitin-independent proteasomal degradation driven by C-degron pathways.

Authors: Authors: Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I.
Mol Cell 2023-06-01
View full abstract on Pubmed