Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.
Authors: Authors: Hoovers JM, Kalikin LM, Johnson LA, Alders M, Redeker B, Law DJ, Bliek J, Steenman M, Benedict M, Wiegant J, Lengauer C, Taillon-Miller P, Schlessinger D, Edwards MC, Elledge SJ, Ivens A, Westerveld A, Little P, Mannens M, Feinberg AP.
Proc Natl Acad Sci U S A
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Finding prospective partners in the library: the two-hybrid system and phage display find a match.
Authors: Authors: Allen JB, Walberg MW, Edwards MC, Elledge SJ.
Trends Biochem Sci
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In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.
Authors: Authors: Eastham JA, Hall SJ, Sehgal I, Wang J, Timme TL, Yang G, Connell-Crowley L, Elledge SJ, Zhang WW, Harper JW, et al.
Cancer Res
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Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
Authors: Authors: Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
J Exp Med
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Authors: Authors: Deng C, Zhang P, Harper JW, Elledge SJ, Leder P.
Cell
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Cyclin D1 provides a link between development and oncogenesis in the retina and breast.
Authors: Authors: Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA.
Cell
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Stopped for repairs.
Authors: Authors: Sanchez Y, Elledge SJ.
Bioessays
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Inhibition of cyclin-dependent kinases by p21.
Authors: Authors: Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, et al.
Mol Biol Cell
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p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Authors: Authors: Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ.
Genes Dev
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p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
Authors: Authors: Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ.
Science
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