Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.
Authors: Authors: Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJ.
Nat Commun
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Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Authors: Authors: Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X.
Nat Commun
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Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
Authors: Authors: Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ.
Genes Dev
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Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids.
Authors: Authors: Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK.
J Immunother Cancer
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High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy.
Authors: Authors: Chen G, Shrock EL, Li MZ, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Phipatanakul W, Schneider L, Oettgen HC, Elledge SJ.
Cell Rep Med
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The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
Authors: Authors: Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ.
Mol Cell
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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Authors: Authors: Martin TD, Patel RS, Cook DR, Choi MY, Patil A, Liang AC, Li MZ, Haigis KM, Elledge SJ.
Science
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CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays.
Authors: Authors: Barber KW, Shrock E, Elledge SJ.
Mol Cell
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Coordinate regulation of the senescent state by selective autophagy.
Authors: Authors: Lee Y, Kim J, Kim MS, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, Kang C.
Dev Cell
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ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Authors: Authors: Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ.
Proc Natl Acad Sci U S A
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