Steven A. McCarroll

Steven A. McCarroll, Ph.D.

Dorothy and Milton Flier Professor of Biomedical Science and Genetics, Harvard Medical School

Director of Genomic Neurobiology, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard

617-432-7794

Publications

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds.

Authors: Authors: Battaglia RA, Bolshakova S, Mazureac I, Liyanage D, Pettinari N, Johnson A, Crouse E, Habib S, Flessas I, Nadig A, Hawes D, Tegtmeyer M, Becker C, Ghosh S, Genovese G, Hogan M, Maglieri A, Barrett LE, Daheron L, McCarroll SA, Nehme R.
bioRxiv 2025-11-09
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Genes and environment profoundly affect the human virome.

Authors: Authors: Kamitaki N, Tang D, McCarroll SA, Loh PR.
bioRxiv 2025-09-11
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Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.

Authors: Authors: Joyce MKP, Ivanov TG, Krienen FM, Mitchell JF, Ma S, Inoue W, Nandy AS, Datta D, Duque A, Arellano JI, Gupta R, Gonzalez-Burgos G, Lewis DA, Sestan N, McCarroll SA, Martinez-Trujillo J, Froudist-Walsh S, Arnsten AFT.
Commun Biol 2025-07-01
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Human genetic variation shapes the response of neurons to interferons.

Authors: Authors: Andzelm MM, Bolshakova S, Pettinari N, Tegtmeyer M, Meyer D, Johnson A, Mello CJ, Yu CT, Mazureac I, Genovese G, Maglieri A, Ichihara K, Hogan M, Hawes D, McCarroll SA, Nehme R.
bioRxiv 2025-05-28
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Transcriptome-wide analysis of differential expression in perturbation atlases.

Authors: Authors: Nadig A, Replogle JM, Pogson AN, Murthy M, McCarroll SA, Weissman JS, Robinson EB, O'Connor LJ.
Nat Genet 2025-05-01
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Explainable modeling of single-cell perturbation data using attention and sparse dictionary learning.

Authors: Authors: Xu Y, Fleming S, Tegtmeyer M, McCarroll SA, Babadi M.
Cell Syst 2025-04-16
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Human and bacterial genetic variation shape oral microbiomes and health.

Authors: Authors: Kamitaki N, Handsaker RE, Hujoel MLA, Mukamel RE, Usher CL, McCarroll SA, Loh PR.
medRxiv 2025-04-01
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Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Authors: Authors: Bunting EL, Donaldson J, Cumming SA, Olive J, Broom E, Miclau? M, Hamilton J, Tegtmeyer M, Zhao HT, Brenton J, Lee WS, Handsaker RE, Li S, Ford B, Ryten M, McCarroll SA, Kordasiewicz HB, Monckton DG, Balmus G, Flower M, Tabrizi SJ.
Sci Transl Med 2025-02-12
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Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.

Authors: Authors: Vartiainen E, Liyanage D, Mazureac I, Battaglia RA, Tegtmeyer M, He JX, Räsänen N, Sealock J, McCarroll S, Nehme R, Pietiläinen O.
bioRxiv 2025-01-28
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Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease.

Authors: Authors: Handsaker RE, Kashin S, Reed NM, Tan S, Lee WS, McDonald TM, Morris K, Kamitaki N, Mullally CD, Morakabati NR, Goldman M, Lind G, Kohli R, Lawton E, Hogan M, Ichihara K, Berretta S, McCarroll SA.
Cell 2025-01-14
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