Susan Dymecki
Susan M. Dymecki, M.D.,Ph.D.
Professor of Genetics

The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.

Understanding how this fundamental system develops at the molecular, cellular, and functional levels will help illuminate root causes of many brain disorders, paving the way for more targeted therapeutics and effective approaches to clinical conditions such as sudden infant death, major depression, and post-traumatic stress.

Using novel genetic tools for precision neural cell mapping in the mouse brain coupled with genomic, transcriptional, electrophysiological, and behavioral analyses, we examine the developmental specialization of subtypes of serotonin-producing neurons together with their network architecture, circuitry modulation, and selective roles in behavior. We probe how such neuronal diversity is generated and maintained, exploring the extent to which it is genetically programmed versus shaped by experience. Emerging is a neuronal structure-function map of substantial heterogeneity that suggests new ways to conceptualize and design treatments for serotonin-related disorders.

Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Authors: Authors: Alekseyenko OV, Chan YB, Okaty BW, Chang Y, Dymecki SM, Kravitz EA.
Curr Biol
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Embracing diversity in the 5-HT neuronal system.
Authors: Authors: Okaty BW, Commons KG, Dymecki SM.
Nat Rev Neurosci
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Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits.
Authors: Authors: Zhou QG, Nemes AD, Lee D, Ro EJ, Zhang J, Nowacki AS, Dymecki SM, Najm IM, Suh H.
J Clin Invest
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Molecular Profiling Defines Evolutionarily Conserved Transcription Factor Signatures of Major Vestibulospinal Neuron Groups.
Authors: Authors: Lunde A, Okaty BW, Dymecki SM, Glover JC.
eNeuro
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Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery.
Authors: Authors: Dosumu-Johnson RT, Cocoran AE, Chang Y, Nattie E, Dymecki SM.
Elife
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Sexual dimorphism of microglia and synapses during mouse postnatal development.
Authors: Authors: Weinhard L, Neniskyte U, Vadisiute A, di Bartolomei G, Ayg├╝n N, Riviere L, Zonfrillo F, Dymecki S, Gross C.
Dev Neurobiol
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Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.
Authors: Authors: Hennessy ML, Corcoran AE, Brust RD, Chang Y, Nattie EE, Dymecki SM.
J Neurosci
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The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Authors: Authors: Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
Cell
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THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.
Authors: Authors: Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH.
Stroke
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Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.
Authors: Authors: Niederkofler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM.
Cell Rep
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