Keith Blackwell headshot
T. Keith Blackwell, Ph.D., M.D.
Professor of Genetics, Joslin Diabetes Center

We use the nematode C. elegans to study processes that defend against environmental, metabolic, and proteotoxic stress, and how these stress defenses influence aging. We are particularly interested in understanding mechanisms that regulate these stress defenses at the level of gene expression, and in how growth and nutrient signals influence these regulatory mechanisms

Oxidative Stress Assays (arsenite and tBHP) in Caenorhabditis elegans.
Authors: Authors: Ewald CY, Hourihan JM, Blackwell TK.
Bio Protoc
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Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.
Authors: Authors: Glover-Cutter KM, Lin S, Blackwell TK.
PLoS Genet
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OMA-gosh, where's that TAF?
Authors: Authors: Blackwell TK, Walker AK.
Cell
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Actigraphy scoring reliability in the study of osteoporotic fractures.
Authors: Authors: Blackwell T, Ancoli-Israel S, Gehrman PR, Schneider JL, Pedula KL, Stone KL.
Sleep
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SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.
Authors: Authors: An JH, Blackwell TK.
Genes Dev
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NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.
Authors: Authors: Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, Alcedo J, Blackwell TK, Hynes NE.
Elife
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TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.
Authors: Authors: Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E.
Dev Biol
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Actigraphy-measured sleep characteristics and risk of falls in older women.
Authors: Authors: Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR.
Arch Intern Med
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Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.
Authors: Authors: An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK.
Proc Natl Acad Sci U S A
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Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial.
Authors: Authors: Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR.
JAMA
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