George Church

George Church, Ph.D.

617-432-7562

Church Lab Website

Publications

Programmable Nucleic Acid Sensing in Human Cells Using Circularizable ssDNA.

Authors: Authors: Mahas A, Ferreira R, Riedmayr LM, Church GM.
Nat Commun 2026-06-05
View full abstract on Pubmed

A platform to design and optimise fluorogenic scFvs for detection of interleukin 33.

Authors: Authors: Reese AE, Karmakar U, Restori M, Hermoso MA, Church GM, Kuru E, Vendrell M.
Chem Sci 2026-05-20
View full abstract on Pubmed

Designing genome editing experiments with EditABLE.

Authors: Authors: Maxim DS, Sostena J, Johnson NS, Wu DW, Charu V, Carter JN, Anand S, Church GM, Bhalla V.
Genome Biol 2026-05-11
View full abstract on Pubmed

Synthetic circuits for cell ratio control.

Authors: Authors: An B, Tang TC, Zhang Q, Wang T, Wang Y, Gan K, Liu K, Zhang DL, Liu Y, Pan YK, Yu M, Shaw WM, Liang Q, Wang Y, Vaiana CA, Lou C, Voigt CA, Lu TK, Church GM, Zhong C.
Nature 2026-05-01
View full abstract on Pubmed

Manufacturing-aware generative models enable petascale synthesis of designed DNA.

Authors: Authors: Weinstein EN, Gollub MG, Slabodkin A, Dobbs K, Cui XB, Gardner CL, Grant RJ, Gurung K, Bailey A, Amin AN, Church GM, Wood EB.
Nat Biotechnol 2026-03-17
View full abstract on Pubmed

A Simple, Ultrastable, and Cost-Effective Oxygen-Scavenging System for Long-Term DNA-PAINT Imaging.

Authors: Authors: Perelman RT, Church GM, Stein J.
Small 2026-02-01
View full abstract on Pubmed

Nutrient requirements of organ-specific metastasis in breast cancer.

Authors: Authors: Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Ramesh DL, Honeder SE, Kumar AS, Wu M, Hansen JA, Shevzov-Zebrun A, Rashan EH, Eghbalian KM, Sivanand S, Barbeau AM, Riedmayr LM, Duquette M, Ali A, Henning N, Trojan SE, Waite M, Kunchok T, Nakano MA, Gourgue F, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG.
Nature 2026-01-01
View full abstract on Pubmed

Engineered base editors with reduced bystander editing through directed evolution.

Authors: Authors: Perrotta RM, Vinke S, Ferreira R, Moret M, Mahas A, Chiappino-Pepe A, Riedmayr LM, Mehra AT, Lehmann LS, Church GM.
Nat Biotechnol 2025-12-18
View full abstract on Pubmed

Plasmid2MC: efficient cell-free generation of high-purity minicircle DNA for genome editing in mammalian cells.

Authors: Authors: Oliynyk RT, Mahas A, Karpinski E, Church GM.
Commun Biol 2025-12-16
View full abstract on Pubmed

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets.

Authors: Authors: Plummer JT, Dezem FS, Cook DP, Park J, Zhang L, Liu Y, Marção M, DuBose H, Wani A, Wise K, Roach M, Harvey K, Wang T, Jensen KB, Morosini N, De Gregorio R, Alonso A, Houlihan SL, Schwartz RE, Hissong E, Snopkowski C, Wrana JL, Ryan N, Butler LM, Church G, Swarbrick A, Mason CE, Martelotto LG.
Nat Biotechnol 2025-12-03
View full abstract on Pubmed