Peter Sicinski headshot

Peter Sicinski, Ph.D., M.D.

Professor of Genetics
617-632-5005
Sicinski Lab Website
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.
Authors: Authors: Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P.
Mol Cell
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CDC7-independent G1/S transition revealed by targeted protein degradation.
Authors: Authors: Suski JM, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W, Can G, Simoneau A, Snioch K, Cup M, Sullivan CM, Wu X, Nowacka J, Branigan TB, Pack LR, DeCaprio JA, Geng Y, Zou L, Gygi SP, Walter JC, Meyer T, Sicinski P.
Nature
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Cyclin E in normal physiology and disease states.
Authors: Authors: Chu C, Geng Y, Zhou Y, Sicinski P.
Trends Cell Biol
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Targeting cell-cycle machinery in cancer.
Authors: Authors: Suski JM, Braun M, Strmiska V, Sicinski P.
Cancer Cell
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Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.
Authors: Authors: Guo Y, Gabola M, Lattanzio R, Paul C, Pinet V, Tang R, Turali H, Bremond J, Longobardi C, Maurizy C, Da Costa Q, Finetti P, Boissière-Michot F, Rivière B, Lemmers C, Garnier S, Bertucci F, Zlobec I, Chebli K, Tazi J, Azar R, Blanchard JM, Sicinski P, Mamessier E, Lemmers B, Hahne M.
J Clin Invest
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Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy.
Authors: Authors: Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W.
Nat Cell Biol
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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells.
Authors: Authors: Michowski W, Chick JM, Chu C, Kolodziejczyk A, Wang Y, Suski JM, Abraham B, Anders L, Day D, Dunkl LM, Li Cheong Man M, Zhang T, Laphanuwat P, Bacon NA, Liu L, Fassl A, Sharma S, Otto T, Jecrois E, Han R, Sweeney KE, Marro S, Wernig M, Geng Y, Moses A, Li C, Gygi SP, Young RA, Sicinski P.
Mol Cell
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Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
Authors: Authors: Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE.
J Am Heart Assoc
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Targeting the cyclin-dependent kinase 5 in metastatic melanoma.
Authors: Authors: Sharma S, Zhang T, Michowski W, Rebecca VW, Xiao M, Ferretti R, Suski JM, Bronson RT, Paulo JA, Frederick D, Fassl A, Boland GM, Geng Y, Lees JA, Medema RH, Herlyn M, Gygi SP, Sicinski P.
Proc Natl Acad Sci U S A
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Chemotherapy and CDK4/6 Inhibition in Cancer Treatment: Timing Is Everything.
Authors: Authors: Fassl A, Sicinski P.
Cancer Cell
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