Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Humoral pregnancy analyses reveal strategies for fetal protection and aberrancy in miscarriage.
Authors: Authors: Sie BM, Leng Y, Nziza N, Mitchell MM, Webb NE, Lee Y, Mumford SL, Schisterman EF, Larman HB, Julg B, Alter G, Elledge SJ.
Cell Rep Med
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Changes in the transcriptome and synthetic lethal dependencies following KRAS mutant expression reveal profound tissue specificity.
Authors: Authors: Martin TD, Choi MY, McBride JC, Elledge SJ.
Proc Natl Acad Sci U S A
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Retraction Note: Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Authors: Authors: Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MIH, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT.
Sci Rep
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The diverse functions of viral microproteins.
Authors: Authors: Chen-Neumann YH, Grauvogel L, Zhang AS, Michaelis AC, Heymann T, Zollbrecht E, Engel P, Pensl C, Yost KE, Suen W, Sinha S, Neumann EN, Elledge SJ, Hopfner KP, Gewurz BE, Mann M, Weissman JS.
bioRxiv
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A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.
Authors: Authors: Fujimura E, O'Leary CN, Li MZ, Roberts RA, Glassman CR, Paulo JA, Jiang H, Abdelfattah NS, Wooten EC, Mirman Z, Harper JW, Cole PA, Elledge SJ.
Cell
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Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion.
Authors: Authors: Glassman CR, Baek K, Hou G, Zeng Q, Nardone C, Juergens KB, Fujimura E, O'Leary CN, Li MZ, Paulo JA, Fischer ES, Ding S, Harper JW, Elledge SJ.
Science
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Persistence of memory: lifespan dynamics of the human antiviral antibody reactome.
Authors: Authors: Mitchell MM, Kula T, Remmel JL, Xia S, Shrock EL, Leng Y, Larman HB, Chen Y, Knip M, Cortese M, Mina MJ, Ascherio A, Elledge SJ.
Nat Commun
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Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance.
Authors: Authors: Shrock EL, Sun E, Dhindsa A, Witwer MH, Yu Z, Ivanochko D, Lee IH, Coventry B, Gonzalez MB, Julien JP, Elledge SJ, Baker D.
bioRxiv
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A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.
Authors: Authors: Jena KK, Qu P, Baracco L, Saghaei S, Allahyari Z, Boehmer D, Mitchell M, Dillen CA, Li HY, Liu E, Poli V, Dufies O, Hoytema van Konijnenburg DP, Spreafico R, Bi C, Hall R, Kruppa MD, Ma Z, Gravitte A, Lowman DW, Ensley HE, Marty P, Boyer L, Collomp R, Williams DL, Ma VP, Lee PY, Nigrovic PA, Karp JM, Elledge SJ, Wesemann DR, Wu Y, Frieman M, Zanoni I.
Nat Immunol
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Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis.
Authors: Authors: Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.
Circulation
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