Stephen Elledge headshot

Stephen J. Elledge, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Authors: Authors: Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.
Genes Dev
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Epstein-Barr Virus Exposure Precedes Crohn`s Disease Development.
Authors: Authors: Nandy A, Petralia F, Porter C, Elledge S, Colombel JF, Snapper SB.
Gastroenterology
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
Authors: Authors: Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X.
bioRxiv
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions.
Authors: Authors: Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V.
Neuron
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An RNA Splicing System that Excises Transposons from Animal mRNAs.
Authors: Authors: Zhao LW, Nardone C, Paulo JA, Elledge SJ, Kennedy S.
bioRxiv
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Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Authors: Authors: Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C.
Nat Commun
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The T cell receptor sequence influences the likelihood of T cell memory formation.
Authors: Authors: Lagattuta KA, Kohlgruber AC, Abdelfattah NS, Nathan A, Rumker L, Birnbaum ME, Elledge SJ, Raychaudhuri S.
Cell Rep
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T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics.
Authors: Authors: Abdelfattah NS, Kula T, Elledge SJ.
Immunity
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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Authors: Authors: Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA.
Nat Commun
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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Authors: Authors: Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA.
Nat Commun
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