Steven McCarroll headshot

Steven A. McCarroll, Ph.D.

Dorothy and Milton Flier Professor of Biomedical Science and Genetics, Harvard Medical School
Director of Genomic Neurobiology, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
617-432-7794
McCarroll Lab Website
Transcriptome-wide analysis of differential expression in perturbation atlases.
Authors: Authors: Nadig A, Replogle JM, Pogson AN, Murthy M, McCarroll SA, Weissman JS, Robinson EB, O'Connor LJ.
Nat Genet
View full abstract on Pubmed
Explainable modeling of single-cell perturbation data using attention and sparse dictionary learning.
Authors: Authors: Xu Y, Fleming S, Tegtmeyer M, McCarroll SA, Babadi M.
Cell Syst
View full abstract on Pubmed
Human and bacterial genetic variation shape oral microbiomes and health.
Authors: Authors: Kamitaki N, Handsaker RE, Hujoel MLA, Mukamel RE, Usher CL, McCarroll SA, Loh PR.
medRxiv
View full abstract on Pubmed
Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.
Authors: Authors: Bunting EL, Donaldson J, Cumming SA, Olive J, Broom E, Miclau? M, Hamilton J, Tegtmeyer M, Zhao HT, Brenton J, Lee WS, Handsaker RE, Li S, Ford B, Ryten M, McCarroll SA, Kordasiewicz HB, Monckton DG, Balmus G, Flower M, Tabrizi SJ.
Sci Transl Med
View full abstract on Pubmed
Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.
Authors: Authors: Vartiainen E, Liyanage D, Mazureac I, Battaglia RA, Tegtmeyer M, He JX, Räsänen N, Sealock J, McCarroll S, Nehme R, Pietiläinen O.
bioRxiv
View full abstract on Pubmed
Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease.
Authors: Authors: Handsaker RE, Kashin S, Reed NM, Tan S, Lee WS, McDonald TM, Morris K, Kamitaki N, Mullally CD, Morakabati NR, Goldman M, Lind G, Kohli R, Lawton E, Hogan M, Ichihara K, Berretta S, McCarroll SA.
Cell
View full abstract on Pubmed
Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.
Authors: Authors: Li R, Taliun SAG, Liao K, Flickinger M, Sobell JL, Genovese G, Locke AE, Chiu RR, LeFaive J, Martins T, Chapman S, Neumann A, Handsaker RE, Arnett DK, Barnes KC, Boerwinkle E, Braff D, Cade BE, Fornage M, Gibbs RA, Hoth KF, Hou L, Kooperberg C, Loos RJF, Metcalf GA, Montgomery CG, Morrison AC, Qin ZS, Redline S, Reiner AP, Rich SS, Rotter JI, Taylor KD, Viaud-Martinez KA, Bigdeli TB, Gabriel S, Zollner S, Smith AV, Abecasis G, McCarroll S, Pato MT, Pato CN, Boehnke M, Knowles J, Kang HM, Ophoff RA, Ernst J, Scott LJ.
medRxiv
View full abstract on Pubmed
Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss.
Authors: Authors: Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat SM, Kentistou KA, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman BR, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman ND, Song L, Gardner EJ, Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ.
Nature
View full abstract on Pubmed
Insights into the causes and consequences of DNA repeat expansions from 700,000 biobank participants.
Authors: Authors: Hujoel MLA, Handsaker RE, Kamitaki N, Mukamel RE, Rubinacci S, Palamara PF, McCarroll SA, Loh PR.
bioRxiv
View full abstract on Pubmed
Calcium-permeable AMPA receptors govern PV neuron feature selectivity.
Authors: Authors: Hong I, Kim J, Hainmueller T, Kim DW, Keijser J, Johnson RC, Park SH, Limjunyawong N, Yang Z, Cheon D, Hwang T, Agarwal A, Cholvin T, Krienen FM, McCarroll SA, Dong X, Leopold DA, Blackshaw S, Sprekeler H, Bergles DE, Bartos M, Brown SP, Huganir RL.
Nature
View full abstract on Pubmed