Brian Seed headshot

Brian Seed, Ph.D.

Professor of Genetics, Harvard Medical School
Principal Investigator, Center for Computational and Integrative Biology, Massachusetts General Hospital
617-726-5975
Seed Lab Website
Intestinal microbes influence development of thymic lymphocytes in early life.
Authors: Authors: Ennamorati M, Vasudevan C, Clerkin K, Halvorsen S, Verma S, Ibrahim S, Prosper S, Porter C, Yeliseyev V, Kim M, Gardecki J, Sassi S, Tearney G, Cherayil BJ, Bry L, Seed B, Jain N.
Proc Natl Acad Sci U S A
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GPR108, an NF-?B activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
Authors: Authors: Dong D, Zhou H, Na SY, Niedra R, Peng Y, Wang H, Seed B, Zhou GL.
PLoS One
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Influence of multiplicative stochastic variation on translational elongation rates.
Authors: Authors: Datta S, Seed B.
PLoS One
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The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Authors: Authors: Davidson D, Zhong MC, Pandolfi PP, Bolland S, Xavier RJ, Seed B, Li X, Gu H, Veillette A.
Cell Rep
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Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.
Authors: Authors: Singhal PK, Sassi S, Lan L, Au P, Halvorsen SC, Fukumura D, Jain RK, Seed B.
Proc Natl Acad Sci U S A
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Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Authors: Authors: Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P.
Mol Cell Biol
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Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption.
Authors: Authors: Zhou GL, Na SY, Niedra R, Seed B.
J Cell Sci
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Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.
Authors: Authors: Luft C, Freeman J, Elliott D, Al-Tamimi N, Kriston-Vizi J, Heintze J, Lindenschmidt I, Seed B, Ketteler R.
BMC Biochem
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Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.
Authors: Authors: Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD.
PLoS Genet
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A high-content imaging workflow to study Grb2 signaling complexes by expression cloning.
Authors: Authors: Freeman J, Kriston-Vizi J, Seed B, Ketteler R.
J Vis Exp
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