Brian Seed

Brian Seed, Ph.D.

Professor of Genetics

617-726-5975

Seed Lab Website

Publications

Enhanced Tim3 activity improves survival after influenza infection.

Authors: Authors: Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD.
J Immunol 2012-09-15
View full abstract on Pubmed

STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

Authors: Authors: Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL.
Bioorg Med Chem 2012-01-15
View full abstract on Pubmed

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.

Authors: Authors: Wang X, Spandidos A, Wang H, Seed B.
Nucleic Acids Res 2012-01-01
View full abstract on Pubmed

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Authors: Authors: Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y.
Bioorg Med Chem Lett 2011-08-01
View full abstract on Pubmed

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.

Authors: Authors: Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX.
Pharmacol Res 2011-04-01
View full abstract on Pubmed

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.

Authors: Authors: Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA.
PLoS One 2011-01-01
View full abstract on Pubmed

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.

Authors: Authors: Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y.
Lab Invest 2010-09-01
View full abstract on Pubmed

The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.

Authors: Authors: Kim H, Seed B.
Nat Immunol 2010-08-01
View full abstract on Pubmed

Host-encoded reporters for the detection and purification of multiple enveloped viruses.

Authors: Authors: Ketteler R, Tomov V, Neunkirchner A, Xie Q, Pickl WF, Seed B.
J Virol Methods 2010-08-01
View full abstract on Pubmed

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Authors: Authors: Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y.
Bioorg Med Chem 2010-06-15
View full abstract on Pubmed