Brian Seed headshot

Brian Seed, Ph.D.

Professor of Genetics, Harvard Medical School
Principal Investigator, Center for Computational and Integrative Biology, Massachusetts General Hospital
617-726-5975
Seed Lab Website
A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.
Authors: Authors: Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B.
BMC Genomics
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Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.
Authors: Authors: Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, McLaughlin M.
Eur J Neurosci
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Quantitation of autophagy by luciferase release assay.
Authors: Authors: Ketteler R, Seed B.
Autophagy
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A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Authors: Authors: Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF.
J Biol Chem
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Spinophilin and the immune synapse.
Authors: Authors: Seed B, Xavier R.
J Cell Biol
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A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.
Authors: Authors: Ketteler R, Sun Z, Kovacs KF, He WW, Seed B.
Genome Biol
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Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes.
Authors: Authors: Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF.
J Allergy Clin Immunol
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General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
Authors: Authors: Kueng HJ, Leb VM, Haiderer D, Raposo G, Thery C, Derdak SV, Schmetterer KG, Neunkirchner A, Sillaber C, Seed B, Pickl WF.
J Virol
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ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.
Authors: Authors: Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW.
J Lipid Res
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Direct stimulation of T lymphocytes by immunosomes: virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules.
Authors: Authors: Derdak SV, Kueng HJ, Leb VM, Neunkirchner A, Schmetterer KG, Bielek E, Majdic O, Knapp W, Seed B, Pickl WF.
Proc Natl Acad Sci U S A
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