Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.
Authors: Authors: Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J.
J Biol Chem
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J Biol Chem
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A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
Authors: Authors: Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA.
Hum Mol Genet
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Hum Mol Genet
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Gene regulation and DNA damage in the ageing human brain.
Authors: Authors: Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA.
Nature
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Nature
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Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Authors: Authors: Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P.
J Biol Chem
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J Biol Chem
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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.
Authors: Authors: Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA.
Nat Med
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Nat Med
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A RIP tide in neuronal signal transduction.
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.
Authors: Authors: Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA.
Neuron
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Neuron
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Inflammation and Alzheimer disease: the good, the bad, and the ugly.
Apoptosis in the nervous system.