Bruce A. Yankner

Bruce A. Yankner, M.D., Ph.D.

Professor of Genetics

617-432-6800

Publications

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.

Authors: Authors: Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE.
Nat Neurosci 2008-04-01
View full abstract on Pubmed

The aging brain.

Authors: Authors: Yankner BA, Lu T, Loerch P.
Annu Rev Pathol 2008-01-01
View full abstract on Pubmed

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium.

Authors: Authors: Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA.
J Biol Chem 2006-09-22
View full abstract on Pubmed

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.

Authors: Authors: Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J.
J Biol Chem 2006-05-19
View full abstract on Pubmed

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

Authors: Authors: Hass MR, Yankner BA.
J Biol Chem 2005-11-04
View full abstract on Pubmed

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Authors: Authors: Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA.
Hum Mol Genet 2005-05-01
View full abstract on Pubmed

Gene regulation and DNA damage in the ageing human brain.

Authors: Authors: Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA.
Nature 2004-06-24
View full abstract on Pubmed

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.

Authors: Authors: Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P.
J Biol Chem 2003-05-30
View full abstract on Pubmed

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.

Authors: Authors: Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA.
Nat Med 2002-06-01
View full abstract on Pubmed

A RIP tide in neuronal signal transduction.

Authors: Authors: Ebinu JO, Yankner BA.
Neuron 2002-05-16
View full abstract on Pubmed