Carla Kim headshot

Carla Kim, Ph.D.

Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
617-919-4644
Kim Lab Website

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Human Airway and Alveolar Organoids from BAL Fluid.
Authors:
Am J Respir Crit Care Med
View full abstract on Pubmed
Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Authors: Authors: Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF.
EMBO J
View full abstract on Pubmed
Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages.
Authors: Authors: Wong IG, Stark J, Ya V, Moye AL, Vazquez AB, Dang SM, Shehaj A, Rouhani MJ, Bronson R, Janes SM, Rowbotham SP, Paschini M, Franklin RA, Kim CF.
bioRxiv
View full abstract on Pubmed
Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors.
Authors: Authors: Rowbotham SP, Pessina P, Garcia-de-Alba C, Jensen J, Nguyen Y, Yoon J, Li J, Wong IG, Fahey C, Moye AL, Chongsaritsinsuk J, Bronson R, Ho Sui SJ, Kim CF.
Dev Cell
View full abstract on Pubmed
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.
Authors: Authors: Li J, Dang SM, Schurmann P, Dost AFM, Moye AL, Paschini M, Bhetariya PJ, Bronson R, Sui SJH, Kim CF.
Res Sq
View full abstract on Pubmed
PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.
Authors: Authors: Adini A, Ko VH, Puder M, Louie SM, Kim CF, Baron J, Matthews BD.
Front Immunol
View full abstract on Pubmed
Progenitor potential of lung epithelial organoid cells in a transplantation model.
Authors: Authors: Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF.
Cell Rep
View full abstract on Pubmed
Comparison of Transplantation of Lung Organoid Cell Types: One Size Does Not Fit All.
Authors: Authors: Ararat E, Louie SM, Lu E, Paschini M, Raiser DM, Kim CF.
Am J Respir Cell Mol Biol
View full abstract on Pubmed
Lung Cancer Stem Cells and Their Clinical Implications.
Authors: Authors: Rowbotham SP, Goruganthu MUL, Arasada RR, Wang WZ, Carbone DP, Kim CF.
Cold Spring Harb Perspect Med
View full abstract on Pubmed
SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung.
Authors: Authors: Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T.
Cancer Discov
View full abstract on Pubmed