Carla Kim headshot

Carla Kim, Ph.D.

Professor of Genetics

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors.
Authors: Authors: Rowbotham SP, Pessina P, Garcia-de-Alba C, Jensen J, Nguyen Y, Yoon J, Li J, Wong IG, Fahey C, Moye AL, Chongsaritsinsuk J, Bronson R, Ho Sui SJ, Kim CF.
Dev Cell
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Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.
Authors: Authors: Li J, Dang SM, Schurmann P, Dost AFM, Moye AL, Paschini M, Bhetariya PJ, Bronson R, Sui SJH, Kim CF.
Res Sq
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PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.
Authors: Authors: Adini A, Ko VH, Puder M, Louie SM, Kim CF, Baron J, Matthews BD.
Front Immunol
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Progenitor potential of lung epithelial organoid cells in a transplantation model.
Authors: Authors: Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF.
Cell Rep
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Comparison of Transplantation of Lung Organoid Cell Types: One Size Does Not Fit All.
Authors: Authors: Ararat E, Louie SM, Lu E, Paschini M, Raiser DM, Kim CF.
Am J Respir Cell Mol Biol
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Lung Cancer Stem Cells and Their Clinical Implications.
Authors: Authors: Rowbotham SP, Goruganthu MUL, Arasada RR, Wang WZ, Carbone DP, Kim CF.
Cold Spring Harb Perspect Med
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SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung.
Authors: Authors: Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T.
Cancer Discov
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The aging lung: Physiology, disease, and immunity.
Authors: Authors: Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MC.
Cell
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Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.
Authors: Authors: Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF.
Cell Stem Cell
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BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.
Authors: Authors: Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, Li C, Oh A, Li F, Hu H, Karatza A, Bronson RT, Shaw AT, Hata AN, Wong KK, Zou L, Carr SA, Jacks T, Kim CF.
Cancer Res
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