Carla Kim, Ph.D.
Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.
Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory
The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research.
Authors: Authors: Saglam-Metiner P, Calkan-Yildirim E, Dogan B, Vaizoglu RD, Celik CE, Goksel O, Yesil-Celiktas O, Pelit L, Kaymaz Y, Kløverpris H, Kwon DS, Kim CF, Koutrakis P, Akdis C, Yilmaz OH, Goksel T.
Thorac Res Pract
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Thorac Res Pract
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Standardized pipeline for establishing, expanding, and differentiating airway and alveolar organoids from human BAL fluid.
Authors: Authors: Gellner TB, Chen B, Raini SR, Jackson MS, Kraak AK, Petta SC, Paschini M, Schnapp LM, Kim CF, Liu MY.
Am J Physiol Lung Cell Mol Physiol
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Am J Physiol Lung Cell Mol Physiol
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Regenerative therapeutics for chronic obstructive pulmonary disease.
Authors: Authors: van der Koog L, Showell HRD, Nugraha DF, Lehmann M, Conlon TM, Yildirim AÖ, Fuentes-Mateos R, Baarsma H, Ng-Blichfeldt JP, Melgert BN, Dost AFM, Burgess JK, Yam SLS, Heijink IH, Ahmed S, Paschini M, Jansen EM, Hinrichs WLJ, Johnson JR, Wu X, Nagelkerke A, Frijlink HW, Kim CF, Gosens R.
Pharmacol Rev
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Pharmacol Rev
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Airway injury induces alveolar epithelial responses mediated by macrophages.
Authors: Authors: Wong IG, Paschini M, Stark J, Vazquez AB, Ya V, Moye AL, Dang SM, Trovero MF, Thompson EL, Ahmed S, Chaudhry FN, Shehaj A, Rouhani MJ, Bronson R, Janes SM, Rowbotham SP, Zepp JA, Franklin RA, Kim CF.
Cell Rep
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Cell Rep
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International evaluation of the SEIZUre Risk in Encephalitis (SEIZURE) score for predicting acute seizure risk.
Authors: Authors: Hughes T, Venkatesan A, Hetherington C, Egbe FN, Netravathi M, Thakur KT, Baykan B, Hui Jan T, Arias S, García-de Soto J, Kahwagi J, Vogrig A, Versace S, Habis R, Sowmitran S, Husari KS, Probasco J, Hasbun R, Bean P, Heck A, GözübatikÇelik GR, Atakli D, Mayda Domac F, Ferreira V, Calado S, Sangeeth TA, Defres S, Romozzi M, Iorio R, Pensato U, Pleshkevich M, Steriade C, Sharifi-Razavi A, Tabrizi N, Sipila J, Kim CY, Diaz-Ariza A, Satish P, Gowda V, Gowda C, Oh SI, Del Carpio-Orantes L, Cotelli M, Ferreira L, Kovalchuk M, Goncharova A, Solomon T, Winkler A, Guekht A, Wood GK, Michael BD.
BMJ Open
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BMJ Open
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Standardized pipeline for establishing, expanding, and differentiating airway and alveolar organoids from human BAL fluid.
Authors: Authors: Gellner TB, Chen B, Raini SR, Jackson MS, Kraak AK, Petta SC, Paschini M, Schnapp LM, Kim CF, Liu MY.
bioRxiv
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bioRxiv
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage.
Authors: Authors: Hoagland DA, Rodríguez-Morales P, Mann AO, Baez Vazquez AY, Yu S, Lai A, Kane H, Dang SM, Lin Y, Thorens L, Begum S, Castro MA, Pope SD, Lim J, Li S, Zhang X, Li MO, Kim CF, Jackson R, Medzhitov R, Franklin RA.
Science
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Science
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Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.
Authors: Authors: Li J, Dang SM, Sengupta S, Schurmann P, Dost AFM, Moye AL, Trovero MF, Ahmed S, Paschini M, Bhetariya PJ, Bronson R, Ho Sui SJ, Kim CF.
EMBO J
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EMBO J
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Human Airway and Alveolar Organoids from BAL Fluid.
Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Authors: Authors: Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF.
EMBO J
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EMBO J
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