Carla Kim, Ph.D.
Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.
Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory
PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.
Authors: Authors: Adini A, Ko VH, Puder M, Louie SM, Kim CF, Baron J, Matthews BD.
Front Immunol
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Front Immunol
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Progenitor potential of lung epithelial organoid cells in a transplantation model.
Authors: Authors: Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF.
Cell Rep
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Cell Rep
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Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium.
Authors: Authors: Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA.
JCI Insight
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JCI Insight
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Comparison of Transplantation of Lung Organoid Cell Types: One Size Does Not Fit All.
Authors: Authors: Ararat E, Louie SM, Lu E, Paschini M, Raiser DM, Kim CF.
Am J Respir Cell Mol Biol
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Am J Respir Cell Mol Biol
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Lung Cancer Stem Cells and Their Clinical Implications.
Authors: Authors: Rowbotham SP, Goruganthu MUL, Arasada RR, Wang WZ, Carbone DP, Kim CF.
Cold Spring Harb Perspect Med
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Cold Spring Harb Perspect Med
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SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung.
Authors: Authors: Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sanchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T.
Cancer Discov
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Cancer Discov
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Genomic and evolutionary classification of lung cancer in never smokers.
Authors: Authors: Zhang T, Joubert P, Ansari-Pour N, Zhao W, Hoang PH, Lokanga R, Moye AL, Rosenbaum J, Gonzalez-Perez A, Martínez-Jiménez F, Castro A, Muscarella LA, Hofman P, Consonni D, Pesatori AC, Kebede M, Li M, Gould Rothberg BE, Peneva I, Schabath MB, Poeta ML, Costantini M, Hirsch D, Heselmeyer-Haddad K, Hutchinson A, Olanich M, Lawrence SM, Lenz P, Duggan M, Bhawsar PMS, Sang J, Kim J, Mendoza L, Saini N, Klimczak LJ, Islam SMA, Otlu B, Khandekar A, Cole N, Stewart DR, Choi J, Brown KM, Caporaso NE, Wilson SH, Pommier Y, Lan Q, Rothman N, Almeida JS, Carter H, Ried T, Kim CF, Lopez-Bigas N, Garcia-Closas M, Shi J, Bossé Y, Zhu B, Gordenin DA, Alexandrov LB, Chanock SJ, Wedge DC, Landi MT.
Nat Genet
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Nat Genet
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National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration.
Authors: Authors: Hynds RE, Zacharias WJ, Nikolic MZ, Königshoff M, Eickelberg O, Gosens R, de Coppi P, Janes SM, Morrisey E, Clevers H, Ryan AL, Stripp BR, Sun X, Kim CF, Lin QS.
Am J Respir Cell Mol Biol
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Am J Respir Cell Mol Biol
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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Authors: Authors: Mulay A, Konda B, Garcia G, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR.
Cell Rep
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Cell Rep
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The aging lung: Physiology, disease, and immunity.
Authors: Authors: Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MC.
Cell
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Cell
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