Carla Kim headshot

Carla Kim, Ph.D.

Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
617-919-4644
Kim Lab Website

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages.
Authors: Authors: Wong IG, Stark J, Ya V, Moye AL, Vazquez AB, Dang SM, Shehaj A, Rouhani MJ, Bronson R, Janes SM, Rowbotham SP, Paschini M, Franklin RA, Kim CF.
bioRxiv
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Epithelial stem and progenitor cells of the upper airway.
Authors: Authors: Rouhani MJ, Janes SM, Kim CF.
Cells Dev
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Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors.
Authors: Authors: Rowbotham SP, Pessina P, Garcia-de-Alba C, Jensen J, Nguyen Y, Yoon J, Li J, Wong IG, Fahey C, Moye AL, Chongsaritsinsuk J, Bronson R, Ho Sui SJ, Kim CF.
Dev Cell
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Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.
Authors: Authors: Li J, Dang SM, Schurmann P, Dost AFM, Moye AL, Paschini M, Bhetariya PJ, Bronson R, Sui SJH, Kim CF.
Res Sq
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Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells.
Authors: Authors: Alysandratos KD, Garcia-de-Alba C, Yao C, Pessina P, Huang J, Villacorta-Martin C, Hix OT, Minakin K, Burgess CL, Bawa P, Murthy A, Konda B, Beers MF, Stripp BR, Kim CF, Kotton DN.
JCI Insight
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PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.
Authors: Authors: Adini A, Ko VH, Puder M, Louie SM, Kim CF, Baron J, Matthews BD.
Front Immunol
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Progenitor potential of lung epithelial organoid cells in a transplantation model.
Authors: Authors: Louie SM, Moye AL, Wong IG, Lu E, Shehaj A, Garcia-de-Alba C, Ararat E, Raby BA, Lu B, Paschini M, Bronson RT, Kim CF.
Cell Rep
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Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium.
Authors: Authors: Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA.
JCI Insight
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Comparison of Transplantation of Lung Organoid Cell Types: One Size Does Not Fit All.
Authors: Authors: Ararat E, Louie SM, Lu E, Paschini M, Raiser DM, Kim CF.
Am J Respir Cell Mol Biol
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Lung Cancer Stem Cells and Their Clinical Implications.
Authors: Authors: Rowbotham SP, Goruganthu MUL, Arasada RR, Wang WZ, Carbone DP, Kim CF.
Cold Spring Harb Perspect Med
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