Carla Kim headshot
Carla Kim, Ph.D.
Professor of Genetics

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information:
http://kim.tchlab.org/

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.
Authors: Authors: Zhu D, Tan J, Maleken AS, Muljadi R, Chan ST, Lau SN, Elgass K, Leaw B, Mockler J, Chambers D, Leeman KT, Kim CF, Wallace EM, Lim R.
Stem Cell Res Ther
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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Authors: Authors: Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF.
EMBO J
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Separating stem cells by flow cytometry: reducing variability for solid tissues.
Authors: Authors: Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.
Cell Stem Cell
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Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.
Authors: Authors: Lee JH, Tammela T, Hofree M, Choi J, Marjanovic ND, Han S, Canner D, Wu K, Paschini M, Bhang DH, Jacks T, Regev A, Kim CF.
Cell
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Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Authors: Authors: Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.
Cell
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Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice.
Authors: Authors: Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola KM, Nolen-Walston RD, Kim CF, Tsai L, Pierce RA, Mecham RP, Ingenito EP.
Am J Physiol Lung Cell Mol Physiol
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Intersections of lung progenitor cells, lung disease and lung cancer.
Authors: Authors: Kim CF.
Eur Respir Rev
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Lung stem and progenitor cells in tissue homeostasis and disease.
Authors: Authors: Leeman KT, Fillmore CM, Kim CF.
Curr Top Dev Biol
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Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts.
Authors: Authors: Raiser DM, Kim CF.
Stem Cells
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Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.
Authors: Authors: Zhang H, Brainson CF, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, Chen Z, Wang X, Akbay EA, Zheng M, Palakurthi S, Sholl LM, Rustgi AK, Kwiatkowski DJ, Alan Diehl J, Bass AJ, Sharpless NE, Dranoff G, Hammerman PS, Ji H, Bardeesy N, Saur D, Watanabe H, Kim CF, Wong KK.
Nat Commun
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