Carla Kim headshot

Carla Kim, Ph.D.

Professor of Genetics
617-919-4644
Kim Lab Website

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Tracing the potential of lung progenitors.
Authors: Authors: Mahoney JE, Kim CF.
Nat Biotechnol
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Developmental biology. Mesenchymal progenitor panoply.
Authors: Authors: Lee JH, Kim CF.
Science
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Non-small-cell lung cancers: a heterogeneous set of diseases.
Authors: Authors: Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK.
Nat Rev Cancer
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Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
Authors: Authors: Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF.
Proc Natl Acad Sci U S A
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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Authors: Authors: Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF.
EMBO J
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Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.
Authors: Authors: Xu C, Fillmore CM, Koyama S, Wu H, Zhao Y, Chen Z, Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A, Reibel JB, Walton Z, Ji H, Watanabe H, Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, Dranoff G, Hammerman PS, Kim CF, Wong KK.
Cancer Cell
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Diverse cells at the origin of lung adenocarcinoma.
Authors: Authors: Rowbotham SP, Kim CF.
Proc Natl Acad Sci U S A
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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Authors: Authors: Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF.
EMBO J
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Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Authors: Authors: Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.
Cell
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Bone marrow-derived multipotent stromal cells attenuate inflammation in obliterative airway disease in mouse tracheal allografts.
Authors: Authors: Casey A, Dirks F, Liang OD, Harrach H, Schuette-Nuetgen K, Leeman K, Kim CF, Gerard C, Subramaniam M.
Stem Cells Int
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