David Sinclair headshot
David Andrew Sinclair, Ph.D.
Professor of Genetics
Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice.
Authors: Authors: Osborne B, Reznick J, Wright LE, Sinclair DA, Cooney GJ, Turner N.
Biochem Biophys Res Commun
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NAD+ in COVID-19 and viral infections.
Authors: Authors: Zheng M, Schultz MB, Sinclair DA.
Trends Immunol
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Applying the AFRAID and FRIGHT clocks to novel preclinical mouse models of polypharmacy.
Authors: Authors: Mach J, Kane AE, Howlett SE, Sinclair DA, Hilmer SN.
J Gerontol A Biol Sci Med Sci
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases.
Authors: Authors: Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA.
Nat Rev Endocrinol
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Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults.
Authors: Authors: Tran T, Pencina KM, Schultz MB, Li Z, Ghattas C, Lau J, Sinclair DA, Montano M.
J Acquir Immune Defic Syndr
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Meeting Report: Aging Research and Drug Discovery.
Authors: Authors: Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.
Aging (Albany NY)
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Dynamic stem cell selection safeguards the genomic integrity of the epidermis.
Authors: Authors: Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK.
Dev Cell
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The 2021 FASEB science research conference on NAD metabolism and signaling.
Authors: Authors: Gorbunova V, Buschbeck M, Cambronne XA, Chellappa K, Corda D, Du J, Freichel M, Gigas J, Green AE, Gu F, Guberovic I, Jayabalan A, Khansahib I, Mukherjee S, Seluanov A, Simon MA, Sverkeli LJ, Kory N, Levine DC, Matic I, Nikiforov A, Rack JGM, Imai SI, Sinclair DA, Toiber D, Zhao Y, Mostoslavsky R, Kraus L, Guse AH.
Aging (Albany NY)
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Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice.
Authors: Authors: Ke S, Mitchell SJ, MacArthur MR, Kane AE, Sinclair DA, Venable EM, Chadaideh KS, Carmody RN, Grodstein F, Mitchell JR, Liu Y.
Nutrients
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Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.
Authors: Authors: Martínez-Greene JA, Hernández-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godínez MDP, Martínez-Martínez E.
J Extracell Vesicles
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