David Sinclair headshot
David Andrew Sinclair, Ph.D.
Professor of Genetics
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.
Authors: Authors: Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ.
Reproduction
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Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.
Authors: Authors: Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP.
Free Radic Biol Med
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
Authors: Authors: Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z.
Redox Biol
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Frailty biomarkers in humans and rodents: current approaches and future advances.
Authors: Authors: Kane AE, Sinclair DA.
Mech Ageing Dev
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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.
Authors: Authors: Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E.
Cell Metab
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Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.
Authors: Authors: Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.
Cell
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Epigenetic changes during aging and their reprogramming potential.
Authors: Authors: Kane AE, Sinclair DA.
Crit Rev Biochem Mol Biol
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Molecular and Cellular Characterization of SIRT1 Allosteric Activators.
Authors: Authors: Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA.
Methods Mol Biol
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Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.
Authors: Authors: Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L.
Nat Rev Cardiol
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Sex differences in the response to dietary restriction in rodents.
Authors: Authors: Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ.
Curr Opin Physiol
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