David Sinclair headshot
David Andrew Sinclair, Ph.D.
Professor of Genetics
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.
Authors: Authors: Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E.
Cell Metab
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Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector.
Authors: Authors: Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Cree W, Daniels T, Danilov M, Daugherty SJ, Daughhetee J, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Didberidze T, Dilling J, Dolgolenko A, Dolinski MJ, Fairbank W, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gornea R, Graham K, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Jamil A, Jewell MJ, Johnson A, Johnston S, Karelin A, Kaufman LJ, Koffas T, Kravitz S, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Leonard DS, Li GS, Li S, Licciardi C, Lin YH, MacLellan R, Michel T, Mong B, Moore D, Murray K, Nelson R, Njoya O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Rowson PC, Russell JJ, Schmidt S, Schubert A, Sinclair D, Stekhanov V, Tarka M, Tolba T, Tsang R, Vogel P, Vuilleumier JL, Wagenpfeil M, Waite A, Walton T, Weber M, Wen LJ, Wichoski U, Wrede G, Yang L, Yen YR, Zeldovich OY, Zettlemoyer J, Ziegler T.
Phys Rev Lett
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Restoring stem cells - all you need is NAD(.).
Authors: Authors: Wu LE, Sinclair DA.
Cell Res
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Authors: Authors: Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.
Nat Commun
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Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.
Authors: Authors: Wu LE, Gomes AP, Sinclair DA.
Cancer Cell
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A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Authors: Authors: Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA.
Mol Cell Biol
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An unSIRTain role in longevity.
Authors: Authors: Accili D, de Cabo R, Sinclair DA.
Nat Med
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Impact papers on aging in 2009.
Authors: Authors: Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.
Aging (Albany NY)
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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
Authors: Authors: Medvedik O, Lamming DW, Kim KD, Sinclair DA.
PLoS Biol
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Life-span extension in yeast.
Authors: Authors: Sinclair DA, Lin SJ, Guarente L.
Science
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