David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

SIRT2 controls the pentose phosphate switch.

Authors: Authors: Wu LE, Sinclair DA.
EMBO J 2014-06-17
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Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies.

Authors: Authors: Uthman OA, Saunders R, Sinclair D, Graves P, Gelband H, Clarke A, Garner P.
BMJ Open 2014-05-14
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The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.

Authors: Authors: Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R.
Cell Rep 2014-03-13
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GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Authors: Authors: Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.
Proc Natl Acad Sci U S A 2014-03-11
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The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.

Authors: Authors: Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ.
Cell Metab 2014-03-04
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Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Authors: Authors: Hubbard BP, Sinclair DA.
Trends Pharmacol Sci 2014-03-01
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Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder.

Authors: Authors: Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon Weickert C.
Transl Psychiatry 2014-02-25
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Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.

Authors: Authors: Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, Anne J, De Franceschi L.
Haematologica 2014-02-01
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Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

Authors: Authors: Wu LE, Gomes AP, Sinclair DA.
Cancer Cell 2014-01-13
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Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.

Authors: Authors: Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J.
PLoS One 2014-01-01
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