David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

Small-molecule allosteric activators of sirtuins.

Authors: Authors: Sinclair DA, Guarente L.
Annu Rev Pharmacol Toxicol 2014-01-01
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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Authors: Authors: Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA.
Cell 2013-12-19
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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Authors: Authors: Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.
Nat Chem Biol 2013-11-01
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A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse.

Authors: Authors: Stottmann RW, Donlin M, Hafner A, Bernard A, Sinclair DA, Beier DR.
Hum Mol Genet 2013-10-15
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Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.

Authors: Authors: Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE.
Angiogenesis 2013-10-01
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Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Authors: Authors: Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA.
J Biol Chem 2013-08-16
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Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Authors: Authors: Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA.
Cell Cycle 2013-07-15
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Germline energetics, aging, and female infertility.

Authors: Authors: Tilly JL, Sinclair DA.
Cell Metab 2013-06-04
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Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.

Authors: Authors: Lai L, Yan L, Gao S, Hu CL, Ge H, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx J, Sinclair DA, Vatner SF, Vatner DE.
Circulation 2013-04-23
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Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Authors: Authors: Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN.
Diabetes 2013-04-01
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