David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector.

Authors: Authors: Ackerman N, Aharmim B, Auger M, Auty DJ, Barbeau PS, Barry K, Bartoszek L, Beauchamp E, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Conti E, Cook J, Cook S, Coppens A, Counts I, Craddock W, Daniels T, Danilov MV, Davis CG, Davis J, deVoe R, Djurcic Z, Dobi A, Dolgolenko AG, Dolinski MJ, Donato K, Dunford M, Fairbank W, Farine J, Fierlinger P, Franco D, Freytag D, Giroux G, Gornea R, Graham K, Gratta G, Green MP, Hägemann C, Hall C, Hall K, Haller G, Hargrove C, Herbst R, Herrin S, Hodgson J, Hughes M, Johnson A, Karelin A, Kaufman LJ, Koffas T, Kuchenkov A, Kumar A, Kumar KS, Leonard DS, Leonard F, LePort F, Mackay D, MacLellan R, Marino M, Martin Y, Mong B, Díez MM, Morgan P, Müller AR, Neilson R, Nelson R, Odian A, O'Sullivan K, Ouellet C, Piepke A, Pocar A, Prescott CY, Pushkin K, Rivas A, Rollin E, Rowson PC, Russell JJ, Sabourov A, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Tosi D, Twelker K, Vogel P, Vuilleumier JL, Vuilleumier JM, Waite A, Waldman S, Walton T, Wamba K, Weber M, Wichoski U, Wodin J, Wright JD, Yang L, Yen YR, Zeldovich OY.
Phys Rev Lett 2011-11-18
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An unSIRTain role in longevity.

Authors: Authors: Accili D, de Cabo R, Sinclair DA.
Nat Med 2011-11-07
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Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.

Authors: Authors: Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J.
Proc Natl Acad Sci U S A 2011-10-25
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A magnetically driven piston pump for ultra-clean applications.

Authors: Authors: LePort F, Neilson R, Barbeau PS, Barry K, Bartoszek L, Counts I, Davis J, deVoe R, Dolinski MJ, Gratta G, Green M, Montero Díez M, Müller AR, O'Sullivan K, Rivas A, Twelker K, Aharmim B, Auger M, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Cook J, Cook S, Craddock W, Daniels T, Dixit M, Dobi A, Donato K, Fairbank W, Farine J, Fierlinger P, Franco D, Giroux G, Gornea R, Graham K, Green C, Hägemann C, Hall C, Hall K, Hallman D, Hargrove C, Herrin S, Hughes M, Hodgson J, Juget F, Kaufman LJ, Karelin A, Ku J, Kuchenkov A, Kumar K, Leonard DS, Lutter G, Mackay D, MacLellan R, Marino M, Mong B, Morgan P, Odian A, Piepke A, Pocar A, Prescott CY, Pushkin K, Rollin E, Rowson PC, Schmoll B, Sinclair D, Skarpaas K, Slutsky S, Stekhanov V, Strickland V, Swift M, Vuilleumier JL, Vuilleumier JM, Wichoski U, Wodin J, Yang L, Yen YR.
Rev Sci Instrum 2011-10-01
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Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.

Authors: Authors: Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F.
EMBO Rep 2011-09-30
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SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.

Authors: Authors: Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michán S, Vianna CR, Sinclair DA, Elias CF, Coppari R.
Cell Metab 2011-09-07
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Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.

Authors: Authors: Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R.
J Biol Chem 2011-06-03
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Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development.

Authors: Authors: Sinclair D, Webster MJ, Wong J, Weickert CS.
Mol Psychiatry 2011-05-01
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Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice.

Authors: Authors: Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE.
Invest Ophthalmol Vis Sci 2011-04-01
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Authors: Authors: Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R.
J Gerontol A Biol Sci Med Sci 2011-02-01
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