David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

SRT1720 improves survival and healthspan of obese mice.

Authors: Authors: Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R.
Sci Rep 2011-01-01
View full abstract on Pubmed

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.

Authors: Authors: Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA.
Aging (Albany NY) 2010-12-01
View full abstract on Pubmed

Characterization of murine SIRT3 transcript variants and corresponding protein products.

Authors: Authors: Yang Y, Hubbard BP, Sinclair DA, Tong Q.
J Cell Biochem 2010-11-01
View full abstract on Pubmed

Dietary restriction: standing up for sirtuins.

Authors: Authors: Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.
Science 2010-08-27
View full abstract on Pubmed

SIRT1 is essential for normal cognitive function and synaptic plasticity.

Authors: Authors: Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD.
J Neurosci 2010-07-21
View full abstract on Pubmed

A blueprint for developing therapeutic approaches that increase healthspan and delay death.

Authors: Authors: Le Couteur DG, Sinclair DA.
J Gerontol A Biol Sci Med Sci 2010-07-01
View full abstract on Pubmed

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.

Authors: Authors: Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M.
Diabetes 2010-04-01
View full abstract on Pubmed

Impact papers on aging in 2009.

Authors: Authors: Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.
Aging (Albany NY) 2010-03-01
View full abstract on Pubmed

Mammalian sirtuins: biological insights and disease relevance.

Authors: Authors: Haigis MC, Sinclair DA.
Annu Rev Pathol 2010-01-01
View full abstract on Pubmed

The ageing epigenome: damaged beyond repair?

Authors: Authors: Sinclair DA, Oberdoerffer P.
Ageing Res Rev 2009-07-01
View full abstract on Pubmed