Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.
Authors: Authors: Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA.
Aging (Albany NY)
View full abstract on Pubmed
Aging (Albany NY)
View full abstract on Pubmed
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.
Authors: Authors: Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P.
Aging Cell
View full abstract on Pubmed
Aging Cell
View full abstract on Pubmed
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.
Authors: Authors: Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH.
Protein Sci
View full abstract on Pubmed
Protein Sci
View full abstract on Pubmed
Aging: past, present and future.
Authors: Authors: Blagosklonny MV, Campisi J, Sinclair DA.
Aging (Albany NY)
View full abstract on Pubmed
Aging (Albany NY)
View full abstract on Pubmed
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Authors: Authors: Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.
Cell
View full abstract on Pubmed
Cell
View full abstract on Pubmed
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Authors: Authors: Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R.
Cell Metab
View full abstract on Pubmed
Cell Metab
View full abstract on Pubmed
Xenohormesis: sensing the chemical cues of other species.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
Authors: Authors: Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA.
PLoS One
View full abstract on Pubmed
PLoS One
View full abstract on Pubmed
What is Xenohormesis?
David A. Sinclair, Ph.D is interviewed by Vicki Glaser.