David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.

Authors: Authors: Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S.
Cell Death Differ 2007-12-01
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Authors: Authors: Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.
Nature 2007-11-29
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The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

Authors: Authors: Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN.
FASEB J 2007-11-01
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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

Authors: Authors: Medvedik O, Lamming DW, Kim KD, Sinclair DA.
PLoS Biol 2007-10-02
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Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Authors: Authors: Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.
Cell 2007-09-21
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The role of nuclear architecture in genomic instability and ageing.

Authors: Authors: Oberdoerffer P, Sinclair DA.
Nat Rev Mol Cell Biol 2007-09-01
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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

Authors: Authors: Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH.
EMBO J 2007-07-11
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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.

Authors: Authors: Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP.
Toxicol Appl Pharmacol 2007-07-01
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Sirtuins in mammals: insights into their biological function.

Authors: Authors: Michan S, Sinclair D.
Biochem J 2007-05-15
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Design and synthesis of compounds that extend yeast replicative lifespan.

Authors: Authors: Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.
Aging Cell 2007-02-01
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