David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
Sirtuins: a conserved key unlocking AceCS activity.
Authors: Authors: North BJ, Sinclair DA.
Trends Biochem Sci
View full abstract on Pubmed
Caloric restriction and life span determination of yeast cells.
Authors: Authors: Medvedik O, Sinclair DA.
Methods Mol Biol
View full abstract on Pubmed
Can we slow aging?
Authors: Authors: Sinclair D, Komaroff AL.
Newsweek
View full abstract on Pubmed
The role of protein arginine methylation in the formation of silent chromatin.
Authors: Authors: Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA.
Genes Dev
View full abstract on Pubmed
Resveratrol improves health and survival of mice on a high-calorie diet.
Authors: Authors: Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA.
Nature
View full abstract on Pubmed
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
Authors: Authors: Yang H, Lavu S, Sinclair DA.
Exp Gerontol
View full abstract on Pubmed
Therapeutic potential of resveratrol: the in vivo evidence.
Authors: Authors: Baur JA, Sinclair DA.
Nat Rev Drug Discov
View full abstract on Pubmed
Life-span extension in yeast.
Authors: Authors: Sinclair DA, Lin SJ, Guarente L.
Science
View full abstract on Pubmed
Unlocking the secrets of longevity genes.
Authors: Authors: Sinclair DA, Guarente L.
Sci Am
View full abstract on Pubmed
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Authors: Authors: Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA.
J Med Chem
View full abstract on Pubmed