David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

HST2 mediates SIR2-independent life-span extension by calorie restriction.

Authors: Authors: Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA.
Science 2005-09-16
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Toward a unified theory of caloric restriction and longevity regulation.

Authors: Authors: Sinclair DA.
Mech Ageing Dev 2005-09-01
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Sirtuins for healthy neurons.

Authors: Authors: Sinclair D.
Nat Genet 2005-04-01
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Authors: Authors: Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D.
Nature 2004-08-05
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Small molecules that regulate lifespan: evidence for xenohormesis.

Authors: Authors: Lamming DW, Wood JG, Sinclair DA.
Mol Microbiol 2004-08-01
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Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae.

Authors: Authors: Mizuno T, Kishimoto T, Shinzato T, Haw R, Chambers A, Wood J, Sinclair D, Uemura H.
Yeast 2004-07-30
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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Authors: Authors: Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.
Science 2004-07-16
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Measurement of the total active 8B solar neutrino flux at the Sudbury Neutrino Observatory with enhanced neutral current sensitivity.

Authors: Authors: Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, Cox GA, Dai X, Dalnoki-Veress F, Doe PJ, Dosanjh RS, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Fleurot F, Formaggio JA, Fowler MM, Frame K, Fulsom BG, Gagnon N, Graham K, Grant DR, Hahn RL, Hall JC, Hallin AL, Hallman ED, Hamer AS, Handler WB, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hemingway RJ, Hime A, Howe MA, Jagam P, Jelley NA, Klein JR, Kos MS, Krumins AV, Kutter T, Kyba CC, Labranche H, Lange R, Law J, Lawson IT, Lesko KT, Leslie JR, Levine I, Luoma S, MacLellan R, Majerus S, Mak HB, Maneira J, Marino AD, McCauley N, McDonald AB, McGee S, McGregor G, Mifflin C, Miknaitis KK, Miller GG, Moffat BA, Nally CW, Nickel BG, Noble AJ, Norman EB, Oblath NS, Okada CE, Ollerhead RW, Orrell JL, Oser SM, Ouellet C, Peeters SJ, Poon AW, Robertson BC, Robertson RG, Rollin E, Rosendahl SS, Rusu VL, Schwendener MH, Simard O, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith MW, Starinsky N, Stokstad RG, Stonehill LC, Tafirout R, Takeuchi Y, Tesic G, Thomson M, Thorman M, Van Berg R, Van de Water RG, Virtue CJ, Wall BL, Waller D, Waltham CE, Tseung HW, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wouters JM, Yeh M, Zuber K.
Phys Rev Lett 2004-05-07
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors: Authors: Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.
Science 2004-03-26
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Constraints on nucleon decay via invisible modes from the Sudbury Neutrino Observatory.

Authors: Authors: Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, Cox GA, Dai X, Dalnoki-Veress F, Doe PJ, Dosanjh RS, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Fleurot F, Formaggio JA, Fowler MM, Frame K, Frati W, Fulsom BG, Gagnon N, Graham K, Grant DR, Hahn RL, Hall JC, Hallin AL, Hallman ED, Hamer AS, Handler WB, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hemingway RJ, Hime A, Howe MA, Jagam P, Jelley NA, Klein JR, Kos MS, Krumins AV, Kutter T, Kyba CC, Labranche H, Lange R, Law J, Lawson IT, Lesko KT, Leslie JR, Levine I, Luoma S, MacLellan R, Majerus S, Mak HB, Maneira J, Marino AD, McCauley N, McDonald AB, McGee S, McGregor G, Mifflin C, Miknaitis KK, Miller GG, Moffat BA, Nally CW, Neubauer MS, Nickel BG, Noble AJ, Norman EB, Oblath NS, Okada CE, Ollerhead RW, Orrell JL, Oser SM, Ouellet C, Peeters SJ, Poon AW, Robertson BC, Robertson RG, Rollin E, Rosendahl SS, Rusu VL, Schwendener MH, Simard O, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith MW, Starinsky N, Stokstad RG, Stonehill LC, Tafirout R, Takeuchi Y, Tesic G, Thomson M, Thorman M, Van Berg R, Van de Water RG, Virtue CJ, Wall BL, Waller D, Waltham CE, Tseung HW, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wittich P, Wouters JM, Yeh M, Zuber K.
Phys Rev Lett 2004-03-12
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