David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.
Authors: Authors: Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.
Mol Cell
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Sirtuin activators and inhibitors: Promises, achievements, and challenges.
Authors: Authors: Dai H, Sinclair DA, Ellis JL, Steegborn C.
Pharmacol Ther
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Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.
Authors: Authors: Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF.
Aging Cell
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Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.
Authors: Authors: Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.
Cell
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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.
Authors: Authors: Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR.
Cell
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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Authors: Authors: Rajman L, Chwalek K, Sinclair DA.
Cell Metab
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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Authors: Authors: Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.
Cell Metab
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Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector.
Authors: Authors: Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Cree W, Daniels T, Danilov M, Daugherty SJ, Daughhetee J, Davis J, Delaquis S, Der Mesrobian-Kabakian A, DeVoe R, Didberidze T, Dilling J, Dolgolenko A, Dolinski MJ, Fairbank W, Farine J, Feyzbakhsh S, Fierlinger P, Fudenberg D, Gornea R, Graham K, Gratta G, Hall C, Hansen EV, Hoessl J, Hufschmidt P, Hughes M, Jamil A, Jewell MJ, Johnson A, Johnston S, Karelin A, Kaufman LJ, Koffas T, Kravitz S, Krücken R, Kuchenkov A, Kumar KS, Lan Y, Leonard DS, Li GS, Li S, Licciardi C, Lin YH, MacLellan R, Michel T, Mong B, Moore D, Murray K, Nelson R, Njoya O, Odian A, Ostrovskiy I, Piepke A, Pocar A, Retière F, Rowson PC, Russell JJ, Schmidt S, Schubert A, Sinclair D, Stekhanov V, Tarka M, Tolba T, Tsang R, Vogel P, Vuilleumier JL, Wagenpfeil M, Waite A, Walton T, Weber M, Wen LJ, Wichoski U, Wrede G, Yang L, Yen YR, Zeldovich OY, Zettlemoyer J, Ziegler T.
Phys Rev Lett
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Assays for NAD+-Dependent Reactions and NAD+ Metabolites.
Authors: Authors: Schultz MB, Lu Y, Braidy N, Sinclair DA.
Methods Mol Biol
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Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.
Authors: Authors: Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, Ayala JE, Gardell SJ, Smith SR.
Mol Metab
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