David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
Assays for NAD+-Dependent Reactions and NAD+ Metabolites.
Authors: Authors: Schultz MB, Lu Y, Braidy N, Sinclair DA.
Methods Mol Biol
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Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.
Authors: Authors: Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N.
Metabolomics
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Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.
Authors: Authors: Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP.
J Gerontol A Biol Sci Med Sci
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Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.
Authors: Authors: Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.
Sci Rep
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Brain antibodies in the cortex and blood of people with schizophrenia and controls.
Authors: Authors: Glass LJ, Sinclair D, Boerrigter D, Naude K, Fung SJ, Brown D, Catts VS, Tooney P, O'Donnell M, Lenroot R, Galletly C, Liu D, Weickert TW, Shannon Weickert C.
Transl Psychiatry
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A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
Authors: Authors: Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.
Science
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SIRT1 protects the heart from ER stress-induced cell death through eIF2a deacetylation.
Authors: Authors: Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C.
Cell Death Differ
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Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).
Authors: Authors: Cronise RJ, Sinclair DA, Bremer AA.
Metab Syndr Relat Disord
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Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.
Authors: Authors: Cronise RJ, Sinclair DA, Bremer AA.
Metab Syndr Relat Disord
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O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Authors: Authors: Ferrer CM, Lu TY, Bacigalupa ZA, Katsetos CD, Sinclair DA, Reginato MJ.
Oncogene
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