David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome.

Authors: Authors: Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ.
eNeuro 2017-01-01
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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

Authors: Authors: Bonkowski MS, Sinclair DA.
Nat Rev Mol Cell Biol 2016-11-01
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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Authors: Authors: Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.
Cell Metab 2016-10-11
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JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Authors: Authors: Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.
Cell Rep 2016-09-06
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Restoring stem cells - all you need is NAD(.).

Authors: Authors: Wu LE, Sinclair DA.
Cell Res 2016-09-01
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Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.

Authors: Authors: Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC.
Aging Cell 2016-08-01
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Why NAD(+) Declines during Aging: It's Destroyed.

Authors: Authors: Schultz MB, Sinclair DA.
Cell Metab 2016-06-14
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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Authors: Authors: Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.
Cell Metab 2016-06-14
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Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability.

Authors: Authors: Kim J, Sturgill D, Tran AD, Sinclair DA, Oberdoerffer P.
Nucleic Acids Res 2016-04-20
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Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.

Authors: Authors: Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC.
Sci Rep 2016-03-18
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