David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.
Authors: Authors: Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC.
Mech Ageing Dev
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SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.
Authors: Authors: Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA.
J Biol Chem
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When stem cells grow old: phenotypes and mechanisms of stem cell aging.
Authors: Authors: Schultz MB, Sinclair DA.
Development
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Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.
Authors: Authors: Uddin GM, Youngson NA, Sinclair DA, Morris MJ.
Front Pharmacol
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Synthesis and Assay of SIRT1-Activating Compounds.
Authors: Authors: Dai H, Ellis JL, Sinclair DA, Hubbard BP.
Methods Enzymol
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Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
Authors: Authors: Winnik S, Auwerx J, Sinclair DA, Matter CM.
Eur Heart J
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Interventions to Slow Aging in Humans: Are We Ready?
Authors: Authors: Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.
Aging Cell
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Oogonial stem cells as a model to study age-associated infertility in women.
Authors: Authors: Garg N, Sinclair DA.
Reprod Fertil Dev
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The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.
Authors: Authors: Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M.
Stem Cell Res
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Authors: Authors: Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.
Nat Commun
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